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Key Documents

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GW22692

Sigma-Aldrich

Anti-CD55 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-CD55

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About This Item

Numero MDL:
MFCD00675552
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

chicken

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

human

Produttore/marchio commerciale

Genway 15-288-22692

tecniche

western blot: suitable

N° accesso NCBI

NP_000565.1

N° accesso UniProt

P08174

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CD55(1604)

Immunogeno

Immunogen Sequence: GI # 10835143, sequence 36-129
Recombinant decay accelerating factor for complement

Applicazioni

Anti-CD55 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Azioni biochim/fisiol

Complement decay-accelerating factor (decay-accelerating factor, DAF) is a protein encoded by the CD55 gene in humans. It plays multiple functions including tissue protection from the cytotoxic complement injury and an anti-inflammatory function due to its anti-adherence properties. It is essential in many organ systems including pregnancy for protection of the semiallogeneic fetus or for preventing uncontrolled infiltration by white cells in their pro- and/or anti-inflammatory functions. Expression of CD55 appears to have multiple regulatory tissue-specific and/or menstrual cycle-specific mechanisms that are involved in complex signaling mechanisms. Its regulation may involve a direct or an indirect effect of at least the estrogen, progesterone, and corticosteroid regulatory pathways. It plays a a primary role in conferring resistance to lysis. CD55 is overexpressed in several types of cancer.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificati d'analisi (COA)

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Yanxia Wu et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(12), G1056-G1064 (2014-04-26)
Engineering cancer cells to express heterologous antigen α-gal and induce the destruction of tumor cells depending on the complement cascade may be a promising strategy of tumor therapy. However, the feasibility and effect of using α-gal to induce colorectal adenocarcinoma
E D Vainer et al.
Tissue antigens, 82(1), 26-34 (2013-05-23)
CD55 (decay-accelerating factor, DAF) is overexpressed in several types of cancer, including colorectal cancer. Because of its inhibitory effect on the complement system, it has been suggested as a possible target for cancer immunotherapy. However, CD55 is also expressed in
Bogdan Nowicki et al.
Advances in experimental medicine and biology, 735, 83-96 (2013-02-14)
In this chapter, we present a concise historic prospective and a summary of accumulated knowledge on steroid hormones, DAF expression, and therapeutic implication of steroid hormone treatment on multiple pathologies, including infection and the host-pathogen interactions. DAF/CD55 plays multiple physiologic

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