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Key Documents

GERPN6302

Iodoacetamide

Cytiva RPN6302, pack of 25 g

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About This Item

Codice UNSPSC:
12352202
NACRES:
NA.77

Forma fisica

solid

Caratteristiche

wetted part: no

Confezionamento

pack of 25 g

Produttore/marchio commerciale

Cytiva RPN6302

Colore

Yellowish

Solubilità

cold water: soluble (Easily soluble in cold and hot water)

Temperatura di conservazione

2-8°C

Categorie correlate

Descrizione generale

Used for the efficient alkylation of thiols while minimizing oxidation of competing thiol pairs in protein samples.

Applicazioni

Iodoacetamide has been used:
  • as a component in urea-sodium dodecyl sulfate (SDS) buffer for yeast cell lysis in immunoprecipitation assay
  • in equilibration of pH gradient strips during the second dimension run in isoelectric focusing
  • as a protein alkylation agent

Azioni biochim/fisiol

Iodoacetamide (IAA) modifies thiol groups in proteins by S-carboxyamidomethylation. Iodoacetamide is an alkylating agent. IAA is commonly used to analyze the key role of cysteine residues in the catalytic reactions of enzymes. It is also used in the derivatization of cysteine residues in proteins for proteomic analysis. IAA irreversibly inhibits glyceraldehyde-3-phosphate dehydrogenase (GAPDH).

Caratteristiche e vantaggi

  • Ultrapure, proteomic-grade iodoacetamide is used for efficient alkylation of thiols while minimizing oxidation of the competing thiol pairs in protein samples.

Stoccaggio e stabilità

Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.

Risultati analitici

To view the Certificate of Analysis for this product, please visit www.cytiva.com.

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301,H334,H317,H413

Codice della classe di stoccaggio

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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3-[(3-colamidopropil)dimetilammonio]-1-propansolfonato BioXtra, ≥98% (TLC)

Sigma-Aldrich

C5070

3-[(3-colamidopropil)dimetilammonio]-1-propansolfonato

Iodoacetic acid ≥98.0% (T)

Sigma-Aldrich

I4386

Iodoacetic acid

Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes
Schmidt M and Dringen R
Frontiers in Neuroenergetics, 1(13), 1-1 (2009)
Proteomic analysis of palmitoylated platelet proteins
Dowal L, et al.
Blood, 118(13), e62-e73 (2011)
Differential Protein Expression in the Nucleus Accumbens and Amygdala of Lewis and Fischer 344 Rats, and its Relevance in Drug Addiction
Roura-Martinez D, et al.
Journal of drug and alcohol research, 6(3), b1-b8 (2014)
COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal
Xu P, et al.
eLife, 6, e28342-e28342 (2017)

Protocolli

Rehydration Solutions

Rehydration Solutions

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