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G0500

Sigma-Aldrich

D-(+)-Galactosamine hydrochloride

≥99% (HPLC)

Sinonimo/i:

2-Amino-2-deoxy-D-galactopyranose hydrochloride, D-Chondrosamine hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C6H13NO5 · HCl
Numero CAS:
1772-03-8
Peso molecolare:
215.63
Beilstein:
3697825
Numero CE:
217-198-1
Numero MDL:
MFCD00135830
Codice UNSPSC:
12352201
ID PubChem:
24894912
NACRES:
NA.25

Saggio

≥99% (HPLC)

Forma fisica

powder

tecniche

HPLC: suitable

Impurezze

≤0.5% Glucosamine (HPAE)

Colore

white to off-white

Punto di fusione

172-180  °C

Solubilità

H2O: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow

Temperatura di conservazione

room temp

Stringa SMILE

Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO

InChI

1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
CBOJBBMQJBVCMW-NQZVPSPJSA-N

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Descrizione generale

D-galactosamine (d-GalN) is a specific hepatotoxic agent metabolized particularly in hepatocytes. It is a 6-carbon amino sugar derived from galactose.

Applicazioni

D-(+)-Galactosamine (D-chondrosamine) has been used with lipopolysaccharides (LPS) to induce models of acute hepatic failure (LPS/D-GalN-induced liver injury, hepatitis) for therapeutic research to find new drugs.
D-(+)-Galactosamine hydrochloride has been used:
  • for the surface binding of mannan-binding lectin (MBL) to modified mica surfaces
  • in sterile phosphate buffer saline (PBS) before the intraperitoneal injection
  • in mice for the generation of primary bone marrow-derived macrophages (BMDMs)

Azioni biochim/fisiol

Galactosamine (Gal) induces hepatocyte death both by necrosis and apoptosis. It prevents the production of liver RNA via the production of uridine diphosphate hexosamines. D-galactosamine lowers the intracellular pool of uracil nucleotides and thereby prevents the production of RNA and proteins.

Altre note

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Sigma-Aldrich

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Sigma-Aldrich

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Xing Lin et al.
Biological & pharmaceutical bulletin, 37(4), 625-632 (2014-05-13)
This study examined the effect of genistein from Hydrocotyle sibthorpioides on lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced acute hepatic failure. Compared to the model control, genistein treatment significantly protected against LPS/D-GalN-induced liver injury, as evidenced by the decrease in serum alanine and aspartate
Yating Li et al.
Applied microbiology and biotechnology, 103(1), 375-393 (2018-10-23)
Acute liver failure is a drastic, unpredictable clinical syndrome with high mortality. Various preventive and adjuvant therapies based on modulating the gut flora have been proposed for hepatic injury. We aimed to explore the preventive and therapeutic effects of Bifidobacterium
Aoxiang Zhuge et al.
Applied microbiology and biotechnology, 104(17), 7437-7455 (2020-07-16)
Acute liver failure is a clinical emergency associated with high mortality. Accumulating evidence indicates that gut microbiota participates in the progression of liver injury, and preventive therapies based on altering gut microbiota are of great interest. Previous studies demonstrated that
Cao-Qi Lei et al.
Journal of immunology (Baltimore, Md. : 1950), 203(1), 259-268 (2019-05-28)
The dynamic regulations of ubiquitination and deubiquitination play important roles in TGF-β-activated kinase 1 (TAK1)-mediated NF-κB activation, which regulates various physiological and pathological events. We identified ubiquitin-specific protease (USP)19 as a negative regulator of TNF-α- and IL-1β-triggered NF-κB activation by
Yinhong Zhu et al.
International immunopharmacology, 72, 131-137 (2019-04-14)
Saikosaponin a (SSa), one of the major active components of Bupleurum falcatum, has antioxidant and anti-inflammatory pharmacological properties. However, the effects of SSa on liver injury have not been reported. In the present study, we evaluated the protective effects and
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