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F2302

Sigma-Aldrich

Fractalkine Peptide

>97% (SDS-PAGE), lyophilized powder, mouse recombinant, expressed in E. coli

Sinonimo/i:

CX3CL-1, Neurotactin

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25 μG
6 350,00 kr

6 350,00 kr

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25 μG
6 350,00 kr

About This Item

Numero MDL:
MFCD01635336
Codice UNSPSC:
51111800
NACRES:
NA.32

6 350,00 kr

Per informazioni sulla disponibilità, contatta il Servizio Clienti.

Nome del prodotto

Fractalkine, Chemokine Domain from mouse, >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Origine biologica

mouse

Livello qualitativo

100

Ricombinante

expressed in E. coli

Saggio

>97% (SDS-PAGE)

Stato

lyophilized powder

Potenza

0.3-3 μg/mL

PM

calculated mol wt ~9.5 kDa

Confezionamento

pkg of 25 μg

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles

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Fractalkine, Chemokine Domain from mouse >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

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Fractalkine, Extracellular Domain human ≥97% (SDS-PAGE), recombinant, expressed in NSO cells, suitable for cell culture, lyophilized powder

F135

Fractalkine, Extracellular Domain human

Follistatin 288 from mouse >95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

F2177

Follistatin 288 from mouse

LIX (CXCL6) from mouse recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

SRP3219

LIX (CXCL6) from mouse

biological source

mouse

biological source

human

biological source

mouse

biological source

mouse

recombinant

expressed in E. coli

recombinant

expressed in NSO cells

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

expressed in E. coli

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

-

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Descrizione generale

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is a membrane protein, which is the only member of CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. It acts as a ligand for the G-protein coupled receptor CX3CR1, which is found on smooth muscle cells, T-cells, natural killer (NK) cells and monocytes. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and neurons.[1]

Azioni biochim/fisiol

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine, along with CX3CR1 is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)-dependent manner. It plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it is thought to be involved in atherogenesis, and thus, might have potential as a target in treatment of cardiovascular disease.[1] In patients with sickle cell disease (SCD), the serum levels of this chemokine is increased, thus implicating it in the pathogenesis of inflammation associated with SCD.[2]
Leukocyte chemoattractant protein and member of the chemokine superfamily possessing a CX3C motif. Mouse fractalkine is chemotactic for neutrophils and T-lymphocytes but not monocytes.

Stato fisico

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.

Risultati analitici

The biological activity is measured by its ability to chemoattract freshly isolated peripheral blood lymphocytes.

Pittogrammi

Corrosion
GHS05

Avvertenze

Danger

Indicazioni di pericolo

H315,H318

Consigli di prudenza

P280 - P305 + P351 + P338

Classi di pericolo

Eye Dam. 1 - Skin Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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    Certificati d'analisi (COA)

    Lot/Batch Number
    SLBG1902V
    SLBG1902
    SLBF4341
    SLBD9259
    SLBD5847

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    Gemma E White et al.
    Arteriosclerosis, thrombosis, and vascular biology, 34(12), 2554-2562 (2014-11-02)
    The CX3C chemokine fractalkine (CX3CL1) has a critical role in the development of atherogenesis because apolipoprotein-E-deficient mice lacking CX3CL1 or its receptor CX3CR1 develop smaller plaques and polymorphisms in CX3CR1 are associated with altered risk of cardiovascular disease. CX3CR1 is
    Selma Unal et al.
    International journal of hematology, 101(2), 114-118 (2014-12-07)
    In the present study, we examined the role of fractalkine (Fkn), a member of the chemokine family, in the pathogenesis of sickle cell disease (SCD). Eighty-seven children with sickle cell disease and 55 healthy children were enrolled in the study.

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