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F1168

Sigma-Aldrich

Fibroblast Growth Factor-9 human

≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

Sinonimo/i:

hGFG-9, FGF-9, GAF, Glial Activating Factor

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About This Item

Numero MDL:
MFCD00677010
Codice UNSPSC:
12352202
NACRES:
NA.32

product name

Fibroblast Growth Factor-9 human, recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE)

Origine biologica

human

Livello qualitativo

100

Ricombinante

expressed in baculovirus infected Sf21 cells

Saggio

≥97% (SDS-PAGE)

Forma fisica

lyophilized powder

Potenza

2.6 ng/mL

PM

~25 kDa

Confezionamento

pkg of 25 μg

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles

tecniche

cell culture | mammalian: suitable

Impurezze

endotoxin, tested

N° accesso UniProt

P31371

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... FGF9(2254)

Descrizione generale

FGF9 (fibroblast growth factor 9) is a member of the FGF family, which consists of a minimum of 24 members. This protein is highly conserved across species, and the gene is localized to human chromosome 13q11-q12. In embryos, FGF9 mRNA has a ubiquitous expression pattern. In adults, this protein has a limited range of expression in normal conditions, and expression is usually restricted to brain, kidney and uterus.

Applicazioni

FGF9 (fibroblast growth factor 9) has been used for the culture of embryonic Sertoli cells obtained from E14.5 testes.

Azioni biochim/fisiol

FGF9 (fibroblast growth factor 9) is expressed in the epithelium and mesothelium of developing lung in the pseudoglandular stage. In developing lungs, it regulates the branching of epithelium, proliferation of mesenchymal cells, and expansion of the lungs. It is overexpressed in patients with idiopathic pulmonary fibrosis (IPF), in regions demonstrating active cell hyperplasia, metaplasia and fibrosis. Thus, it might facilitate the pathogenesis of IPF. The expression of this protein is up-regulated in colon cancer, which is an outcome of hypoxia-induced translational activation.
Mitogenic for glial cells, fibroblasts, and oligodendrocyte type 2 astrocyte progenitor cells; not mitogenic for endothelial cells. Like aFGF and bFGF, FGF-9 has no secretory signal sequence.

Stato fisico

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 1.25 mg bovine serum albumin.

Risultati analitici

The biological activity is measured in a bioassay using BALB/3T3 cells.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Fibroblast growth factors (FGFs).
Vainikka, S., et al. et al.
Guidebook to Cytokines and Their Receptors, 214-214 (1994)
Louise Willerton et al.
The International journal of developmental biology, 48(7), 637-643 (2004-10-08)
Proliferation and cord formation by embryonic Sertoli cells are pivotal events involved in testis morphogenesis. A number of growth factors have been implicated in mediating these events. However, the exact level of involvement and importance of each as yet remains
Emily Coffey et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 61(9), 671-679 (2013-06-26)
The fibroblast growth factor (FGF) family of signaling ligands contributes significantly to lung development and maintenance in the adult. FGF9 is involved in control of epithelial branching and mesenchymal proliferation and expansion in developing lungs. However, its activity and expression
M Miyamoto et al.
Molecular and cellular biology, 13(7), 4251-4259 (1993-07-01)
Glia-activating factor (GAF) is a novel heparin-binding growth factor purified from the culture supernatant of a human glioma cell line. It shows a spectrum of activity slightly different from those of other known growth factors. We have isolated the cDNA
Tsung-Ming Chen et al.
Nucleic acids research, 42(5), 2932-2944 (2013-12-18)
Human fibroblast growth factor 9 (FGF9) is a potent mitogen involved in many physiological processes. Although FGF9 messenger RNA (mRNA) is ubiquitously expressed in embryos, FGF9 protein expression is generally low and restricted to a few adult organs. Aberrant expression

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