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E9145

Sigma-Aldrich

Estrone 3-sulfate potassium salt

≥98%

Sinonimo/i:

1,3,5(10)-Estratrien-17-one 3-sulfate

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About This Item

Formula condensata:
C18H21O5SK
Numero CAS:
1240-04-6
Peso molecolare:
388.52
Numero CE:
214-985-1
Numero MDL:
MFCD00056410
Codice UNSPSC:
51111800
ID PubChem:
24894691
NACRES:
NA.77

Livello qualitativo

200

Saggio

≥98%

Stato

powder

contiene

~35% Tris as stabilizer

Colore

off-white to light tan

Solubilità

methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

Condizioni di spedizione

ambient

Temperatura di conservazione

−20°C

Stringa SMILE

[K].[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24

InChI

1S/C18H22O5S.K.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,18+;;/m1../s1
XFQXTMKDDYWSBS-DLEHHZMWSA-N

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Azioni biochim/fisiol

The most abundant estrogen in adult human circulation. Conversion to estradiol requires steroid sulfatase activity. This activity was used to evaluate freshly resected bone fragments against cultured osteoblasts and osteosearcoma cells as models for studying human bone metabolism.

Confezionamento

Package size based on steroid content

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Warning

Indicazioni di pericolo

H319,H335,H361

Classi di pericolo

Eye Irrit. 2 - Repr. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
058M4083V
107M4038V
126M4024V
015M4063V
13140208

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Estrone ≥99%

Sigma-Aldrich

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Sigma-Aldrich

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β-Estradiol 3-(β-D-glucuronide) sodium salt

Sigma-Aldrich

E2127

β-Estradiol 3-(β-D-glucuronide) sodium salt

p-Aminohippuric acid ≥99%

Sigma-Aldrich

A1422

p-Aminohippuric acid

Equilin

Sigma-Aldrich

E8126

Equilin

Estriol ≥97%

Sigma-Aldrich

E1253

Estriol

Dehydroepiandrosterone 3-sulfate (DHEAS) sodium salt solution 1.0 mg/mL in methanol (as free sulfate), ampule of 1 mL, certified reference material, Cerilliant®

Supelco

D-065

Dehydroepiandrosterone 3-sulfate (DHEAS) sodium salt solution

Digoxin analytical standard

Supelco

D6003

Digoxin

Maria Karlgren et al.
Journal of medicinal chemistry, 55(10), 4740-4763 (2012-05-01)
The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug interactions. Predicting potential interactions with OATPs is, therefore, of value. Here, we developed in vitro and in silico models
Anna Koenen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(4), 774-780 (2012-09-18)
Previously, the steroid hormone progesterone has been demonstrated to stimulate OATP2B1-mediated transport of estrone-3-sulphate (E(1)S), dehydroepiandrosterone sulphate (DHEAS) and pregnenolone sulphate (PS), which may influence the uptake of precursor molecules for steroid hormone synthesis. However, it is unclear whether OATP2B1
L M M C Sousa et al.
Placenta, 33(10), 788-794 (2012-07-31)
Our objectives were to investigate the possible role of VEGFA in bovine placenta steroid synthesis and to determine whether cloned derived placental cells present similar responses as non-cloned ones. Placental cells from cloned (term) and non-cloned (days 90, 150, 210
Elizabeth J Folkerd et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 30(24), 2977-2980 (2012-07-18)
To investigate whether suppression of plasma estradiol and estrone sulfate levels by the aromatase inhibitors (AIs) anastrozole and letrozole is related to body mass index (BMI) in postmenopausal women with early estrogen receptor (ER) -positive breast cancer. Recent studies have
Anne Mette Lund Würtz et al.
Cancer causes & control : CCC, 23(10), 1711-1720 (2012-08-29)
Levels of endogenous estrogen and SHBG are associated with risk of breast cancer among women who have never used hormone replacement therapy (HRT). We investigated these associations in both never and baseline users of HRT. A nested case-control study was
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