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E2127

Sigma-Aldrich

β-Estradiol 3-(β-D-glucuronide) sodium salt

Sinonimo/i:

1,3,5(10)-Estratriene-3,17β-diol 3-glucuronide, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-glucuronide

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About This Item

Formula condensata:
C24H31O8Na
Numero CAS:
14982-12-8
Peso molecolare:
470.49
Numero MDL:
MFCD00056552
Codice UNSPSC:
51111800
ID PubChem:
24894454
NACRES:
NA.77

Sterilità

non-sterile

Saggio

≥98% (HPLC)

Forma fisica

powder

Solubilità

water: 10 mg/mL, clear to slightly hazy

Condizioni di spedizione

ambient

Temperatura di conservazione

−20°C

Stringa SMILE

[Na].CC12CCC3C(CCc4cc(OC5OC(C(O)C(O)C5O)C(O)=O)ccc34)C1CCC2O

InChI

1S/C24H32O8.Na.H/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30;;/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30);;
JKYLXXZHJUQLMK-UHFFFAOYSA-N

Applicazioni

β-Estradiol 3-(β-D-glucuronide) sodium salt has been used in estrogen administration. It has also been used to determine the amount of two types of glucuronidated estradiols such as estradiol-3- α glucuronide and estradiol-17- β glucuronide.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302 + H312 + H332

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

P3635

5β-Pregnane-3α,20α-diol glucuronide

Estrone 3-sulfate potassium salt ≥98%

Sigma-Aldrich

E9145

Estrone 3-sulfate potassium salt

Mohamed-Eslam F Mohamed et al.
Xenobiotica; the fate of foreign compounds in biological systems, 40(10), 663-669 (2010-07-30)
Commonly used herbal supplements were screened for their potential to inhibit UGT1A1 activity using human liver microsomes. Extracts screened included ginseng, echinacea, black cohosh, milk thistle, garlic, valerian, saw palmetto, and green tea epigallocatechin gallate (EGCG). Estradiol-3-O-glucuronide (E-3-G) formation was
K S Kan et al.
The Biochemical journal, 261(1), 297-300 (1989-07-01)
By using rat liver perfusion under one-pass conditions with a single pulse of horseradish peroxidase (HRP), the biliary output of HRP was used as an indicator of paracellular permeability change caused by the cholestatic compound oestradiol 17 beta-glucuronide (E17G). Since
N Kanai et al.
The American journal of physiology, 270(2 Pt 2), F326-F331 (1996-02-01)
Although substantial evidence indicates that estradiol-17 beta (E2) is conjugated to the glucuronide in the kidney and then excreted by a direct tubular secretory route and that the liver transports E2 glucuronides via carrier-mediated mechanisms, the transporters involved in these
M H Rae et al.
Clinica chimica acta; international journal of clinical chemistry, 176(1), 71-81 (1988-08-15)
Urinary oestrone-3-glucuronide, oestradiol-3-glucuronide, oestrone and oestradiol were measured by radioimmunoassay methods adapted for the very low levels found in postmenopausal women. Oestrogen concentrations related to creatinine in morning urine samples from ten postmenopausal women were found to correlate well with
[Contraception per computer. Hormone system persona--results of studies in Germany].
G Freundl et al.
Fortschritte der Medizin, 116(9), 47-48 (1998-05-13)
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Separation of Estriol 3-(β-D-glucuronide) sodium salt; β-Estradiol 3-(β-D-glucuronide) 17-sulfate dipotassium salt; Estriol 3-sulfate sodium salt; β-Estradiol 3,17-disulfate dipotassium salt, ≥95%; β-Estradiol 17-(β-D-glucuronide) sodium salt; β-Estradiol 3-(β-D-glucuronide) sodium salt; Estrone 3-(β-D-glucuronide) sodium salt; β-Estradiol 3-sulfate sodium salt, ≥93%; Estriol, ≥97%; Estrone 3-sulfate sodium salt, contains ~35% Tris as stabilizer; β-Estradiol, ≥98%; α-Estradiol, powder, ≥98% (TLC); Estrone, ≥99%

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