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E5406

Sigma-Aldrich

Ethopropazine hydrochloride

≥98% (HPLC), powder

Sinonimo/i:

Dibutil, Parkin

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About This Item

Formula empirica (notazione di Hill):
C19H24N2S · HCl
Numero CAS:
1094-08-2
Peso molecolare:
348.93
Numero CE:
214-134-4
Numero MDL:
MFCD00012653
Codice UNSPSC:
12352200
ID PubChem:
329799070
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

powder

Condizioni di stoccaggio

desiccated

Colore

white

Solubilità

DMSO: >5 mg/mL at ~60 °C, clear

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl[H].CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13

InChI

1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H
VXPCQISYVPFYRK-UHFFFAOYSA-N

Informazioni sul gene

human ... CHRM1(1128)

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Descrizione generale

Ethopropazine hydrochloride possess anticholinergic, antihistamine and antiadrenergic properties.

Azioni biochim/fisiol

Ethoproprazine hydrochloride is an inhibitor of butyrylcholinesterase; antiparkinsonian
Ethoproprazine hydrochloride is an inhibitor of butyrylcholinesterase; antiparkinsonian. It reduces extrapyramidal motor effects, characteristic of Parkinson′s disease; also alleviates thermal hyperalgesia in rats.

Caratteristiche e vantaggi

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
096M4753V
055M4711V
012M4707V
031M4744V
098K47142

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Physostigmine salicylate European Pharmacopoeia (EP) Reference Standard

P1600000

Physostigmine salicylate

Solfato di sodio puriss., meets analytical specification of Ph. Eur., BP, USP, anhydrous, 99.0-100.5% (calc. to the dried substance)

Sigma-Aldrich

13464

Solfato di sodio

Carboxylesterase 1 isoform b human recombinant, expressed in baculovirus infected BTI insect cells

Sigma-Aldrich

E0287

Carboxylesterase 1 isoform b human

Acetylthiocholine iodide ≥99.0% (AT)

Sigma-Aldrich

01480

Acetylthiocholine iodide

Bis(p-nitrophenyl) phosphate sodium salt ≥99% (TLC)

Sigma-Aldrich

N3002

Bis(p-nitrophenyl) phosphate sodium salt

Derek P Narendra et al.
PLoS biology, 8(1), e1000298-e1000298 (2010-02-04)
Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin recognizes damaged mitochondria, however, is unknown. Here, we
Transition Metal Complexes of Ethopropazine: Synthesis and Characterization
Debbeti V, et al.
American Journal of Chemistry, 2(6), 294-298 (2012)
Katherine C M Chew et al.
PloS one, 6(5), e19720-e19720 (2011-06-01)
Mutations in the parkin gene, which encodes a ubiquitin ligase (E3), are a major cause of autosomal recessive parkinsonism. Although parkin-mediated ubiquitination was initially linked to protein degradation, accumulating evidence suggests that the enzyme is capable of catalyzing multiple forms
Min Fu et al.
Molecular biology of the cell, 24(8), 1153-1162 (2013-02-22)
Glycoprotein 78 (Gp78) is a critical E3 ubiquitin ligase in endoplasmic reticulum-associated degradation. Overexpression of Flag-tagged Gp78 (Flag-gp78), but not Flag-gp78 mutated in its RING-finger domain (Flag-RINGmut) with deficient ubiquitin ligase activity, induces mitochondrial fragmentation and ubiquitination and proteasome-dependent degradation
Louis de Léséleuc et al.
PLoS neglected tropical diseases, 7(1), e2015-e2015 (2013-01-26)
Leprosy is a persistent infectious disease caused by Mycobacterium leprae that still affects over 200,000 new patients annually. The host genetic background is an important risk factor for leprosy susceptibility and the PARK2 gene is a replicated leprosy susceptibility candidate
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Articoli

Acetylcholine Synthesis and Metabolism

Acetylcholine is synthesized from acetyl coenzyme A and choline by the enzyme choline acetyltransferase. In addition to its synthesis in the liver, choline employed in acetylcholine production is derived from dietary sources.

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