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E4632

Sigma-Aldrich

Econazole nitrate salt

Sinonimo/i:

1-(2-[(4-Chlorophenyl)methoxy]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole

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About This Item

Formula empirica (notazione di Hill):
C18H15Cl3N2O · HNO3
Numero CAS:
24169-02-6
Peso molecolare:
444.70
Numero CE:
246-053-5
Numero MDL:
MFCD00058160
Codice UNSPSC:
51102829
ID PubChem:
24894567
NACRES:
NA.85

Forma fisica

powder or crystals

Livello qualitativo

200

Colore

white to off-white

Spettro attività antibiotica

Gram-positive bacteria
fungi

Modalità d’azione

cell membrane | interferes
cell wall synthesis | interferes
enzyme | inhibits

Stringa SMILE

O[N+]([O-])=O.Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1

InChI

1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
DDXORDQKGIZAME-UHFFFAOYSA-N

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Descrizione generale

Chemical structure: imidazole

Applicazioni

Econazole is a broad spectrum antimycotic similar to ketoconazole. It has some action against Gram positive bacteria. It is used topically in dermatomycoses as well as orally and parenterally. It is used for studies on processes such as platelet serotonin uptake, prostanoid biosynthesis, EDHF-mediated relaxation, and Ca2+ transport pathways in thymic lymphocytes.

Azioni biochim/fisiol

Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H319

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Clotrimazole

Sigma-Aldrich

C6019

Clotrimazole

USP

USP

1443409

Miconazole

Holmium(III) oxide ≥99.9% (rare earth content, expressed as Ho2O3)

Sigma-Aldrich

H9750

Holmium(III) oxide

Ketoconazole Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1385

Ketoconazole

Clotrimazole Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1058

Clotrimazole

Terbinafine

Sigma-Aldrich

T8826

Terbinafine

Emetine dihydrochloride

Sigma-Aldrich

E2375

Emetine dihydrochloride

Itraconazole ≥98% (HPLC)

Sigma-Aldrich

I6657

Itraconazole

Atrazine PESTANAL®, analytical standard

Supelco

45330

Atrazine

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Alessandro Malara et al.
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Abscisic acid (ABA) is a phytohormone involved in pivotal physiological functions in higher plants. Recently, ABA has been proven to be also secreted and active in mammals, where it stimulates the activity of innate immune cells, mesenchymal and hematopoietic stem
C J Jackson et al.
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Azole antifungals are central to therapy and act by inhibiting a cytochrome P450, sterol 14-demethylase and blocking normal sterol synthesis. Our recent identification of a mycobacterial sterol biosynthetic pathway led us to probe the efficacy of a range of these
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M. J. Mason, B. Mayer, et al.
American Journal of Physiology. Cell Physiology, 264, C654-C662 (1993)
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A viability quantitative PCR (v-qPCR) assay was developed for the unambiguous detection and quantification of Lactobacillus plantarum PM411 viable cells in aerial plant surfaces. A 972-bp region of a PM411 predicted prophage with mosaic architecture enabled the identification of a
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