T8826

Terbinafine

• Sinonimo/i: trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine
• Formula empirica (notazione di Hill): C₂₁H₂₅N · HCl
• Numero CAS: 78628-80-5
• Peso molecolare: 327.89
• Numero MDL: MFCD00145430
• Codice UNSPSC: 51302503
• ID PubChem: 329826887
• NACRES: NA.85

Proprietà

• Saggio: ≥98%
• Forma fisica: powder
• Colore: white to faint beige
• Solubilità: methanol: soluble 50 mg/mL
• Spettro attività antibiotica: fungi; yeast
• Modalità d’azione: enzyme | inhibits
• Stringa SMILE: Cl[H].[H]\C(CN(C)Cc1cccc2ccccc12)=C(\[H])C#CC(C)(C)C
• InChI: 1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;; BWMISRWJRUSYEX-SZKNIZGXSA-N

Descrizione

Descrizione generale

Allylamine derivative.

Applicazioni

Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.

Azioni biochim/fisiol

Mode of Action: Inhibits squalene epoxidase, preventing biosynthesis of ergosterol.Antimicrobial spectrum: Antifungal and antimycotic. Fungicidal against dermatopytes and some yeasts; fungistatic against Candida albicans.

Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. The inhibition of squalene monooxygenase also results in the accumulation of squalene. Terbinafine hydrochloride is highly lipophilic and tends to accumulate in skin, nails, and fatty tissues. It is antifungal and antimycotic. It is fungicidal against dermatopytes and some yeasts and is fungistatic against Candida albicans.

Altre note

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Esclusione di responsabilità

The product is not intendedfor use as a biocide under global biocide regulations, including but notlimited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, EuropeanBiocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’sBiocidal Products Regulation, Korea’s Consumer Chemical Products and BiocideSafety Management Act (K-BPR) and others.

Informazioni sulla sicurezza

• Pittogrammi: GHS07,GHS09
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335,H410
• Consigli di prudenza: P261 - P264 - P271 - P273 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves