F8929

Fluconazole

≥98% (HPLC), powder, fungal cytochrome P-450 sterol C-14 α-demethyllation inhibitor

• Sinonimo/i: 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
• Formula empirica (notazione di Hill): C₁₃H₁₂F₂N₆O
• Numero CAS: 86386-73-4
• Peso molecolare: 306.27
• Numero MDL: MFCD00274549
• Codice UNSPSC: 12352200
• ID PubChem: 24724485
• NACRES: NA.77

Proprietà

• Nome del prodotto: Fluconazole, ≥98% (HPLC), powder
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Solubilità: DMSO: 5 mg/mL
• Spettro attività antibiotica: fungi
• Modalità d’azione: enzyme | inhibits
• Temperatura di conservazione: room temp
• Stringa SMILE: FC1=CC(F)=C(C(CN2N=CN=C2)(O)CN3N=CN=C3)C=C1
• InChI: 1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2; RFHAOTPXVQNOHP-UHFFFAOYSA-N
• Informazioni sul gene: human ... CYP1A2(1544)

Descrizione

Descrizione generale

Fluconazole is used to treat adult neutropenic patients with invasive candidiasis (IC).

Applicazioni

Fluconazole has been used to assess minimum inhibitory concentration (MIC)-fungal assay. It has also been used as a positive control in antifungal assay of plants.

Azioni biochim/fisiol

Fluconazole is an antifungal agent. It is highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H360D,H362,H412
• Consigli di prudenza: P202 - P260 - P263 - P273 - P301 + P312 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Aquatic Chronic 3 - Lact. - Repr. 1B
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves