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Key Documents

D8638

Sigma-Aldrich

Dodecyltrimethylammonium bromide

≥98%

Sinonimo/i:

Lauryltrimethylammonium bromide

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About This Item

Formula condensata:
CH3(CH2)11N(CH3)3Br
Numero CAS:
Peso molecolare:
308.34
Beilstein:
3597463
Numero CE:
Numero MDL:
Codice UNSPSC:
12161900
ID PubChem:
NACRES:
NA.25

Origine biologica

synthetic (oragnic)

Livello qualitativo

Descrizione

cationic

Saggio

≥98%

Forma fisica

powder

PM

308.34 g/mol

Punto di fusione

246 °C (dec.) (lit.)

Solubilità

954 g/L at 20 °C

Densità

1.17 g/cm3 at 20 °C (68 °F)

Stringa SMILE

[Br-].CCCCCCCCCCCC[N+](C)(C)C

InChI

1S/C15H34N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16(2,3)4;/h5-15H2,1-4H3;1H/q+1;/p-1
XJWSAJYUBXQQDR-UHFFFAOYSA-M

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Descrizione generale

Dodecyltrimethylammonium bromide (DTAB) is a versatile quaternary ammonium surfactant with a wide range of applications in cell biology and biochemical research. Its unique properties make it a valuable tool for solubilizing proteins and peptides, extracting DNA, and lysing cells. In proteomics research, DTAB plays a crucial role in protein solubilization and purification. Its ability to disrupt hydrophobic interactions and electrostatic forces allows it to effectively solubilize membrane-bound proteins and peptides, making them accessible for analysis and characterization. This property is particularly important in proteomics studies involving membrane proteins, which are often difficult to solubilize using conventional methods.

Beyond protein solubilization, this cationic detergent also finds application in DNA extraction procedures. Its ability to interact with DNA and alter its conformation facilitates the release of DNA from cellular components, enabling its subsequent purification and analysis. This property is particularly useful in the isolation of DNA from various biological samples, including tissues, cells, and microorganisms. Furthermore, DTAB demonstrates effectiveness in cell lysis processes. Its ability to disrupt cell membranes and release intracellular components makes it a valuable tool for breaking down cells and accessing their contents. This property has applications in various biological studies, including protein extraction, enzyme assays, and cellular component analysis.

Dodecyltrimethylammonium bromide (DTAB) stands as a versatile and widely applicable surfactant with a diverse range of applications in proteomics research, cell biology, and biochemical research. Its ability to solubilize proteins and peptides, extract DNA, and lyse cells makes it an essential tool for various biological studies and analytical techniques.

Applicazioni

Dodecyltrimethylammonium bromide has been used in a study to assess the distribution of binary mixed counterions in surfactant adsorbed films. It has also been used in a study to investigate chain length compatibility of surfactants for extraction of organophosphorous pesticides.
Dodecyltrimethylammonium bromide has been used to lyse neonatal normal human epidermal keratinocyte (NHEK) cells for the quantification of intracellular nicotinamide adenine dinucleotide phosphate (NADP+) and NADPH (reduced form) content.

Caratteristiche e vantaggi

High-quality compound for your cell biology and biochemical research

Altre note

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Avvertenze

Danger

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


Certificati d'analisi (COA)

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Study on the distribution of binary mixed counterions in surfactant adsorbed films by total reflection XAFS measurements
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Journal of Colloid and Interface Science, 15, 219-224 (2012)
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Free radical biology & medicine, 99, 608-622 (2016-10-23)
Resveratrol has gained tremendous interest owing to multiple reported health-beneficial effects. However, the underlying key mechanism of action of this natural product remained largely controversial. Here, we demonstrate that under physiologically relevant conditions major biological effects of resveratrol can be
Xiaofeng Chang et al.
Journal of colloid and interface science, 377(1), 291-298 (2012-04-28)
This study reported, for the first time systematically, photodegradation of Rhodamine B (RhB) in aqueous solution over BiOCl and BiOBr semiconductors. Under visible light irradiation (λ>400 nm, λ>420 nm and λ=550±15 nm), RhB adsorbed on the surface of BiOCl and
Jonas Carlstedt et al.
Physical chemistry chemical physics : PCCP, 14(27), 9574-9577 (2012-06-14)
Polyelectrolytes with amphiphilic counterions, PEACs, are water insoluble because the amphiphiles self-assemble into highly charged micelles that strongly associate with the equally highly charged polyions. However, in the presence of water soluble cyclodextrins (CDs) that form inclusion complexes with the
Ye Liu et al.
Lab on a chip, 12(19), 3746-3753 (2012-07-31)
Although biochemical sensing using liquid crystals (LC) has been demonstrated, relatively little attention has been paid towards the fabrication of in situ-formed LC sensing devices. Herein, we demonstrate a highly reproducible method to create uniform LC thin film on treated

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