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D7802

Sigma-Aldrich

Daidzein

≥98% (TLC), powder, carbonic anhydrase (CA) inhibitor

Sinonimo/i:

4′,7-Dihydroxy­iso­flavone, 7-Hydroxy-3-(4-hydroxy­phenyl)-4H-1-benzo­pyran-4-one, 7-Hydroxy-3-(4-hydroxy­phenyl)­chromone, Isoaurostatin

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About This Item

Formula empirica (notazione di Hill):
C15H10O4
Numero CAS:
486-66-8
Peso molecolare:
254.24
Beilstein:
231523
Numero CE:
207-635-4
Numero MDL:
MFCD00016954
Codice UNSPSC:
12352202
ID PubChem:
24278030
NACRES:
NA.77

product name

Daidzein, ≥98%, synthetic

Origine biologica

synthetic

Livello qualitativo

200

Saggio

≥98%

Forma fisica

powder

Punto di fusione

>290 °C

Solubilità

DMSO: 10 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

Oc1ccc(cc1)C2=COc3cc(O)ccc3C2=O

InChI

1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H
ZQSIJRDFPHDXIC-UHFFFAOYSA-N

Informazioni sul gene

human ... ESR1(2099) , ESR2(2100) , UGT1A4(54657)
mouse ... Aldh1a2(19378) , Hexa(15211) , Maoa(17161)
rat ... Aldh1a2(116676)

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Descrizione generale

Daidzein is an isoflavone present in soy. It regulates oxidative stress, angiogenesis, cell growth and apoptosis. Daidzein has antioxidant, antiestrogenic and antiatherogenic properties. It provides protection against osteoporosis.

Applicazioni

Daidzein has been used:
  • as a control to evaluate fertility in rats
  • to study its effects on ovarian cancer
  • to simulate in vitro antioxidant activity

Azioni biochim/fisiol

Soy isoflavone daidzein protects against oxidative damage in liver cells induced by 7,12-dimethylbenz[a]anthracene (DMBA). Catalase and superoxide dismutase activity, down-regulated by DMBA, was restored by daidzein.
Daidzein is a phytoestrogen that is suggested to play a role in preventing hormone-induced cancers. Arrests cell cycle at G1 in Swiss 3T3 cells.

Confezionamento

Packaged under Argon.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Genistin from Glycine max (soybean), ≥95% (HPLC)

Sigma-Aldrich

G0897

Genistin

S-Equol ≥97% (HPLC)

Sigma-Aldrich

SML2147

S-Equol

Biochanin A

Sigma-Aldrich

D2016

Biochanin A

Genistein analytical standard

Supelco

92136

Genistein

Glycitin ≥98% (HPLC)

Sigma-Aldrich

G1296

Glycitin

(±)-Equol ≥99.0% (TLC)

Sigma-Aldrich

45405

(±)-Equol

Formononetin ≥99.0% (TLC)

Sigma-Aldrich

47752

Formononetin

N Sathyamoorthy et al.
Cancer research, 54(4), 957-961 (1994-02-15)
Epidemiological studies suggest a lowered risk of hormone-dependent cancers among vegetarians, but the basis for this association remains unclear. Vegetables and fruits contain certain compounds which can be converted to biologically active hormone-like substances, such as lignans and isoflavones, by
Comparison of the effects of mesquite pod and Leucaena extracts with phytoestrogens on the reproductive physiology and sexual behavior in the male rat
Retana-Marquez S, et al.
Physiology & Behavior, 164, 1-10 (2016)
Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer
Chan KKL, et al.
Cancer Cell International, 18(1), 65-65 (2018)
K Higashi et al.
Biochimica et biophysica acta, 1221(1), 29-35 (1994-03-10)
An isoflavone compound, daidzein, inhibits the cell proliferation of Swiss 3T3 cells. Analysis of entry in S phase of Swiss 3T3 cells reveals that daidzein blocked cell cycle G1 phase progression 4.6 h after stimulation by bombesin plus insulin. After
Mesquite (Prosopis juliflora) pod extract decreases fertility in female but not male rats
Retana-Marquez S, et al.
African Journal of Pharmacy and Pharmacology, 10(46), 984-994 (2016)
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