D6899
Diclofenac
Sinonimo/i:
Acido 2-[(2,6-diclorofenil)amino]benzeneacetico
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
About This Item
Formula empirica (notazione di Hill):
C14H10Cl2NNaO2
Numero CAS:
Peso molecolare:
318.13
Numero CE:
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Origine biologica
synthetic
Saggio
≥98% (TLC)
Stato
powder
Punto di fusione
283-285 °C
Solubilità
methanol: 50 mg/mL, clear, colorless to faint yellow or tan
Ideatore
Novartis
Temperatura di conservazione
room temp
Stringa SMILE
[Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
InChI
1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
KPHWPUGNDIVLNH-UHFFFAOYSA-M
Informazioni sul gene
human ... PTGS1(5742) , PTGS2(5743)
Cerchi prodotti simili? Visita Guida al confronto tra prodotti
Categorie correlate
Applicazioni
Diclofenac sodium has been used:
- to investigate its radioprotective potential in a study
- to determine the basic viscosity and hydrodynamic values of the solubilizers and their micellar adducts in a study
- as a standard for potentiometric and fluorimetric determination of diclofenac in a sequential injection analysis system
- to inhibit phase II drug metabolizing enzyme (DME) in a study to investigate the inhibitory effects of an ethanol extract of Descurainia sophia seeds on Phase I and II DMEs
Azioni biochim/fisiol
FANS e inibitore della ciclossigenasi (COX) di tipo standard. I metaboliti principali sono 4´-idrossidiclofenac e 5´-idrossidiclofenac. È stato usato come substrato selettivo per il CYP2C9.
Diclofenac sodium salt is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a competitive and irreversible inhibitor of prostaglandin synthetase. Its analgesic and anti-inflammatory activities are based on the prevention of the synthesis of arachinodate metabolites via cyclooxygenase inhibition. It is found to hinder the conversion of arachidonic acid to prostaglandins, which mediate inflammatory process. The NSAIDs are found to inhibit both cyclooxygenase enzymes, COX-1 and COX-2, causing undesirable gastrointestinal effect. Diclofenac sodium also functions as a scavenger of free radicals and serves a radioprotective role in restoring supercoiled form of plasmid DNA damaged by radiation back to normal. Diclofenac sodium is oxidized by the donation of electron and transfer of hydrogen atom. It can be a potential radioprotective agent.
Caratteristiche e vantaggi
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1
Codice della classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
I clienti hanno visto anche
Amit Alok et al.
Mutation research, 755(2), 156-162 (2013-07-06)
The potential of clinical drug diclofenac sodium which is routinely used in clinics as non-steroid anti-inflammatory drugs opens a new insight in development of radioprotector. The drug has shown its potential radioprotective efficacy in clonogenic cell survival in Chinese hamster
Simultaneous potentiometric and fluorimetric determination of diclofenac in a sequential injection analysis system
Analytica Chimica Acta, 470, 185-194 (2002)
Diclofenac sodium (GP 45840, Voltaren), a potent inhibitor of prostaglandin synthetase.
E C Ku et al.
Biochemical pharmacology, 24(5), 641-643 (1975-03-01)
Jin-Mu Yi et al.
BMC complementary and alternative medicine, 15, 441-441 (2015-12-20)
Descurainia sophia seeds have a variety of pharmacological functions and been widely used in traditional folk medicine. However, their effects on human drug metabolizing enzyme (DME) activities have not been elucidated. The present study investigated the inhibitory effects of an
Seung-Hwan Jung et al.
Redox biology, 37, 101751-101751 (2020-10-21)
Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with various side effects, including cardiovascular and hepatic disorders. Studies suggest that mitochondrial damage and oxidative stress are important mediators of toxicity, yet the underlying mechanisms are poorly understood. In this study
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.