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Merck
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Key Documents

Altri documenti

D6571

Sigma-Aldrich

3′,4′-Dimethoxyflavone

Sinonimo/i:

2-(3,4-Dimethoxyphenyl)chromen-4-one, 3′,4′-DMF

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About This Item

Formula empirica (notazione di Hill):
C17H14O4
Numero CAS:
4143-62-8
Peso molecolare:
282.29
Numero MDL:
MFCD00143009
Codice UNSPSC:
12352200
ID PubChem:
329798831
NACRES:
NA.77

Saggio

≥98% (HPLC)

Livello qualitativo

100

Forma fisica

powder

Colore

white to off-white

Solubilità

DMSO: ≥20 mg/mL

Temperatura di conservazione

room temp

Stringa SMILE

COc1ccc(cc1OC)C2=CC(=O)c3ccccc3O2

InChI

1S/C17H14O4/c1-19-15-8-7-11(9-17(15)20-2)16-10-13(18)12-5-3-4-6-14(12)21-16/h3-10H,1-2H3
ZGHORMOOTZTQFL-UHFFFAOYSA-N

Applicazioni

3′,4′-Dimethoxyflavone has been used in urease inhibition assay.

Azioni biochim/fisiol

3′,4′-Dimethoxyflavone is a flavone compound, which has the ability to prevent the production and accumulation of poly (ADP-ribose) (PAR) polymer. It guards against N-methyl-D-aspartate (NMDA) toxicity in cortical neurons. 3′,4′-Dimethoxyflavone is a member of the class of plant-derived polyphenolic flavonoids. It is known to have antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidemic and neuroprotective or neurotrophic effects.
3′,4′-dimethoxyflavone is a competitive antagonist of the AhR that inhibits AhR-mediated induction of CYP1A1, and also displays antiestrogen activity in breast tumor cell lines. The compound blocks transformation of the cytosolic AhR complex, and formation of nuclear AhR complexes.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Flavonoids as natural inhibitors of jack bean urease Enzyme
AJ Awllia, et al.
Letters in Drug Design & Discovery, 13(3), 243-249 (2016)
Identification through high-throughput screening of 4'-methoxyflavone and 3', 4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos
Fatokun AA, et al.
British Journal of Pharmacology, 169(6), 1263-1278 (2013)
Nada H Eisa et al.
International journal of molecular sciences, 21(21) (2020-10-30)
There is increasing evidence of the involvement of the tryptophan metabolite kynurenine (KYN) in disrupting osteogenesis and contributing to aging-related bone loss. Here, we show that KYN has an effect on bone resorption by increasing osteoclastogenesis. We have previously reported
Ke Wang et al.
International journal of molecular sciences, 16(7), 16454-16468 (2015-07-25)
Exposure to aristolochic acid I (AAI) can lead to aristolochic acid nephropathy (AAN), Balkan endemic nephropathy (BEN) and urothelial cancer. The induction of hepatic CYP1A, especially CYP1A2, was considered to detoxify AAI so as to reduce its nephrotoxicity. We previously

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