D193

DL-α-Difluoromethylornithine hydrochloride hydrate

≥97% (NMR), solid, polyamine biosynthesis inhibitor

• Sinonimo/i: 2-(Difluoromethyl)ornithine hydrochloride hydrate, DFMO hydrochloride hydrate, Eflornithine hydrochloride hydrate
• Formula empirica (notazione di Hill): C₆H₁₂F₂N₂O₂ · xHCl · yH₂O
• Numero CAS: 70052-12-9
• Peso molecolare: 182.17 (anhydrous free base basis)
• Numero MDL: MFCD00242734
• Codice UNSPSC: 12352200
• ID PubChem: 24278809
• NACRES: NA.77

Proprietà

• product name: DL-α-Difluoromethylornithine hydrochloride hydrate, solid, ≥97% (NMR)
• Saggio: ≥97% (NMR)
• Forma fisica: solid
• Colore: white
• Solubilità: DMSO: >10 mg/mL; H₂O: >10 mg/mL
• Stringa SMILE: O.Cl.NCCCC(N)(C(F)F)C(O)=O
• InChI: 1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2; FJPAMFNRCFEGSD-UHFFFAOYSA-N
• Informazioni sul gene: human ... ODC1(4953)

Descrizione

Descrizione generale

Difluoromethylornithine is a fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic effects on mammalian cells and tissues.

Applicazioni

DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line.

Azioni biochim/fisiol

Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)