C6022

Cyproheptadine hydrochloride sesquihydrate

≥98% (TLC), solid

• Sinonimo/i: Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride, hydrate (2:3)
• Formula empirica (notazione di Hill): C₂₁H₂₁N·HCl·1.5H₂O
• Numero CAS: 41354-29-4
• Peso molecolare: 350.88
• Numero CE: 213-535-1
• Codice UNSPSC: 12352200
• ID PubChem: 24278082
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (TLC)
• Forma fisica: solid
• Colore: white to slightly yellow
• Solubilità: ethanol: soluble; methanol: soluble
• Ideatore: Merck & Co., Inc., Kenilworth, NJ, U.S.
• Stringa SMILE: Cl.CN1CCC(\CC1)=C2/c3ccccc3C=Cc4ccccc24
• InChI: 1S/2C21H21N.2ClH.3H2O/c2*1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;;;;/h2*2-11H,12-15H2,1H3;2*1H;3*1H2; ZEAUHIZSRUAMQG-UHFFFAOYSA-N
• Informazioni sul gene: human ... HRH1(3269) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

Descrizione

Applicazioni

Cyproheptadine hydrochloride sesquihydrate has been used in:

• testing anti-inflammatory activity in serotonin receptor (5-HT) induced inflammation
• the inhibition of 5-HT in in vivo and in vitro bioassays in crabs
• the inhibition of 5-HT in embryo physiological experiments

inhibition of calcitonin gene related peptide (CGRP)

Azioni biochim/fisiol

Cyproheptadine hydrochloride sesquihydrate is a serotonin receptor (5-HT2/5-HT1C) antagonist, H1 histamine receptor antagonist and an antipruritic. The inhibition of 5-HT by cyproheptadine improves cognitive function in schizophrenia disorder. Cyproheptadine is effective for treating functional gastrointestinal disorders (FGIDs). Food and Drug Administration (FDA) approved cyproheptadine, has antidepressant and antiplatelet functionality. It may be effective in treating thromboembolic disorders. Cyproheptadine inhibits lysine methyltransferase 7/9 (Set7/9) leading to a decrease in estrogen receptor (ERα) expression and growth arrest in breast cancer cells.

Caratteristiche e vantaggi

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H315,H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves