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C4895

Sigma-Aldrich

Cephalexin hydrate

first-generation cephalosporin antibiotic

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About This Item

Formula empirica (notazione di Hill):
C16H17N3O4S · xH2O
Numero CAS:
1820673-23-1
Peso molecolare:
347.39 (anhydrous basis)
Beilstein:
965503
Numero CE:
239-773-6
Numero MDL:
MFCD00056877
Codice UNSPSC:
51282503
ID PubChem:
24278316
NACRES:
NA.85

Livello qualitativo

200

Stato

powder

pKa 

5.2
7.3

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria

Modalità d’azione

cell wall synthesis | interferes

Temperatura di conservazione

2-8°C

InChI

1S/C16H17N3O4S.H2O/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9;/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23);1H2/t10-,11-,15?;/m1./s1
AVGYWQBCYZHHPN-FNOHQHCYSA-N

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Descrizione generale

Chemical structure: ß-lactam

Applicazioni

Cephalexin is a cephalosporin antibiotic used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.

Azioni biochim/fisiol

Cephalexin disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cephalexin antibiotics mimic the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan.

Altre note

Storage of this product should be in airtight containers and protected from light.

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H317,H334

Classi di pericolo

Resp. Sens. 1 - Skin Sens. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000223890
098M4776V
088M4759V
088M4758V
117M4827V

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