C3993

Carvedilol

≥98% (HPLC), solid

• Sinonimo/i: 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol, BM-14190
• Formula empirica (notazione di Hill): C₂₄H₂₆N₂O₄
• Numero CAS: 72956-09-3
• Peso molecolare: 406.47
• Numero MDL: MFCD00864692
• Codice UNSPSC: 12352200
• ID PubChem: 329775050
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Colore: white to off-white
• Solubilità: DMSO: >20 mg/mL
• Ideatore: GlaxoSmithKline
• Stringa SMILE: OC(COC1=CC=CC2=C1C3=C(C=CC=C3)N2)CNCCOC4=CC=CC=C4OC
• InChI: 1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3; OGHNVEJMJSYVRP-UHFFFAOYSA-N
• Informazioni sul gene: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRB1(153) , ADRB2(154) , ADRB3(155)

Descrizione

Applicazioni

Carvedilol has been used:

• as a β blocker to determine its effect on hypoxia inducible factor (HIF)-mediated erythropoiesis under hypoxia in vivo
• as a βAR antagonist for inhibition of bARs
• as a β-blocker to examine airway mechanics in fungus-challenged mice

Azioni biochim/fisiol

Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity. Carvedilol is used specifically for the treatment of heart failure and high blood pressure. It has been shown to improve left ventricular ejection fraction and may reduce mortality.

Caratteristiche e vantaggi

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS09
• Avvertenze: Warning
• Indicazioni di pericolo: H373,H411
• Consigli di prudenza: P260 - P273 - P314 - P391 - P501
• Classi di pericolo: Aquatic Chronic 2 - STOT RE 2
• Organi bersaglio: Liver,spleen,Uterus (including cervix),Adrenal gland
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves