C3660
Complement C9 from human serum
≥150,000 C9H50 units/mg (using C9 deficient serum)
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About This Item
Prodotti consigliati
Origine biologica
human
Livello qualitativo
Saggio
≥85% (SDS-GE)
Forma fisica
solution
Attività specifica
≥150,000 C9H50 units/mg (using C9 deficient serum)
N° accesso UniProt
applicazioni
cell analysis
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... C9(735)
Applicazioni
Complement C9 from human serum is an essential part of the terminal complement system. It has been a topic in cancer research, where extracellular phosphorylation by ecto-PK of K562 cells on serine residues may serve as a protective mechanism against complement in tumor cells. Additionally, it can be used as a biomarker (in fucosylated form) for squamous cell lung cancer, as patients tend to show elevated levels of C9 protein.
Azioni biochim/fisiol
Complement component C9 is the final component of the membrane attack complex (MAC) responsible for cell lysis by complement. CD59 binds to both C8 and C9 and prevents assembly of an active MAC, protecting cells against lytic activity.
Qualità
Functionally pure by a sensitive hemolytic assay using deficient sera.
Stato fisico
Supplied as a solution in phosphate buffered saline, pH 7.2.
Altre note
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Esclusione di responsabilità
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Codice della classe di stoccaggio
10 - Combustible liquids
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Archives of biochemistry and biophysics, 316(2), 780-788 (1995-02-01)
Ecto-protein kinases (ecto-PK), primarily of the serine/threonine kinase type, have been previously described on the surface of various normal, transformed, and tumor cells. We have found that in the presence of ATP and Mg2+, exogenously added substrates such as phosvitin
Phosphorylation of the complement component, C9, by an ecto-protein kinase of human leukemic cells
Immunopharmacology and Immunotoxicology, 42, 175-785 (1999)
PloS one, 13(6), e0198472-e0198472 (2018-06-13)
Immunoproteomic analysis was performed to identify unknown, pathology-related molecules in patients with seronegative (SN) obstetric antiphospholipid syndrome (APS) who clinically satisfied the diagnostic criteria for APS, but not the serological criteria. We collected peripheral blood from 13 SN-APS outpatients with
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