C2992

CFTR Inhibitor-172

≥98% (HPLC), powder, CFTR inhibitor

• Sinonimo/i: 5-[(4-Carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl-4-thiazolidinone
• Formula empirica (notazione di Hill): C₁₈H₁₀F₃NO₃S₂
• Numero CAS: 307510-92-5
• Peso molecolare: 409.40
• Numero MDL: MFCD06411408
• Codice UNSPSC: 12352200
• ID PubChem: 24724436
• NACRES: NA.77

Proprietà

• Nome del prodotto: CFTR(inh)-172, ≥98% (HPLC), powder
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: yellow
• Solubilità: DMSO: ≥10 mg/mL; H₂O: insoluble
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: OC(=O)c1ccc(cc1)\C=C2\SC(=S)N(C2=O)c3cccc(c3)C(F)(F)F
• InChI: 1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8+; JIMHYXZZCWVCMI-RIYZIHGNSA-N

Descrizione

Applicazioni

CFTR(inh)-172 has been used to specifically inhibit cystic fibrosis transmembrane conductance regulator (CFTR) activity. It is also used as a CFTR inhibitor Inh-172 to treat forskolin and IBMX.

Azioni biochim/fisiol

CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR).

CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). With a K_i = 300 nM,. CFTR(inh)-172 leads to rapid, reversible and voltage-independent inhibition; it is an antidiarrheal agent in animals. CTFR(inh)-172 may be a useful tool to study animal models of cystic fibrosis and intestinal fluid loss in cholera and other secretory diarrheas. CTFR(inh)-172 is structurally-unrelated to known, but non-specific CFTR inhibitors DPC, NPPB (Cat. No. N4779) and Glibenclamide.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves