P2928

Paxilline

powder, ≥98% (HPLC)

• Formula empirica (notazione di Hill): C₂₇H₃₃NO₄
• Numero CAS: 57186-25-1
• Peso molecolare: 435.56
• Numero MDL: MFCD00083464
• Codice UNSPSC: 12352200
• ID PubChem: 24898374
• NACRES: NA.77

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: faintly yellow
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CC(C)(O)C1OC2CCC3(C)C(O)(CCC4Cc5c([nH]c6ccccc56)C34C)C2=CC1=O
• InChI: 1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1; ACNHBCIZLNNLRS-UBGQALKQSA-N

Descrizione

Descrizione generale

Paxilline is an indole diterpene metabolite produced by fungi. It has a functionalized pentacyclic core and is a template for the synthesis of a wide variety of derivatives.

Applicazioni

Paxilline has been used to block large conductance calcium activated potassium channels (BKCa) in murine smooth muscle cells and in myometrial cells of uterine samples. Paxilline acts as an agonist and activates liver X receptor in atlantic salmon.

Azioni biochim/fisiol

Paxilline is a selective blocker of high-conductance Ca₂⁺-activated (Maxi-K) potassium channels. It also blocks big potassium (BK) channels.

Caratteristiche e vantaggi

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Altre note

Major toxin in Penicillium paxilli

Informazioni sulla sicurezza

• Pittogrammi: GHS05,GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301 + H311 + H331 - H315 - H318 - H335
• Consigli di prudenza: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges