C2363

Monoclonal Anti-phospho-β-Catenin (pSer³³) antibody produced in mouse

clone BC-76, purified immunoglobulin, buffered aqueous solution

• Numero MDL: MFCD04040943
• Codice UNSPSC: 12352203
• NACRES: NA.41
• Coniugato: unconjugated
• application: ARR; WB
• Clone: BC-76, monoclonal
• Reattività contro le specie: human
• citations: 5
• tecniche: microarray: suitable; western blot: 5 μg/mL using total cell extracts of cultured HEK-293T cells treated with MG132

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 200
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: BC-76, monoclonal
• Stato: buffered aqueous solution
• Reattività contro le specie: human
• tecniche: microarray: suitable; western blot: 5 μg/mL using total cell extracts of cultured HEK-293T cells treated with MG132
• Isotipo: IgM
• N° accesso UniProt: P35222
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: phosphorylation (pSer33)
• Informazioni sul gene: human ... CTNNB1(1499)

Descrizione

Descrizione generale

Cateninβ is a multifunctional protein, coded by CTNNB1 (cateninβ 1) gene. It is present in the intracellular side of the cytoplasmic membrane. It is located on human chromosome 3p22.1.

Immunogeno

synthetic phosphopeptide corresponding to the region that contains serine 33 of human β-catenin.

Applicazioni

Monoclonal Anti-phospho-β-Catenin (pSer³³) antibody produced in mouse is suitable for microarray and western blotting at a concentration of 5μg/mL using total cell extracts of cultured HEK-293T cells treated with MG132.

Azioni biochim/fisiol

Catenin (cadherin-associated protein), β 1 (88kDa) protein is encoded by CTNNB1 gene in humans. It is also called as β-catenin. It is a dual function protein that regulates the coordination of cell-cell adhesion and gene transcription. Human β-catenin is located at band p21 on chromosome 3.

Mutations in β-catenin results in retinal vascular condition FEVR (familial exudative vitreoretinopathy). It participates in stimulating disease progression, providing BCR–ABL (fusion gene) kinase-independent resistance and LSC (leukemic stem cell) self-renewal. CTNNB1 plays an important role in cell-to-cell adhesion and transcriptional modulation in the Wnt signalling pathway.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.