C0768

Cyclophosphamide monohydrate

bulk package

• Sinonimo/i: 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan
• Formula empirica (notazione di Hill): C₇H₁₅Cl₂N₂O₂P · H₂O
• Numero CAS: 6055-19-2
• Peso molecolare: 279.10
• Beilstein: 4678992
• Numero CE: 200-015-4
• Numero MDL: MFCD00149395
• Codice UNSPSC: 51112507
• ID PubChem: 57653979
• NACRES: NA.77

Proprietà

• Livello qualitativo: 200
• Saggio: 97.0-103.0% (HPLC)
• Stato: powder
• Punto di fusione: 49-51 °C (lit.)
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: [H]O[H].ClCCN(CCCl)P1(=O)NCCCO1
• InChI: 1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2; PWOQRKCAHTVFLB-UHFFFAOYSA-N
• Informazioni sul gene: human ... ALDH1A1(216) , ALDH1B1(219)

Descrizione

Descrizione generale

Cyclophosphamide (CYC) is a cytotoxic alkylating agent. It is activated by the cytochrome P-450 enzyme system in the liver. It has immunomodulatory functionality and inhibits humoral and cellular immunity.Cyclophosphamide exhibits anti-cancer and immunosuppressant activities. In the body, cyclophosphamide is converted by the liver to an active alkylating 4-hydroxycyclophosphamide metabolite, thereby showing its anti-neoplastic effects.

Applicazioni

Cyclophosphamide monohydrate has been used:

• to test its antitumor effect on TC-1 tumor cells
• as a component of multidrug solution for isolation of resistant human burkitt lymphoma cell line
• in testing antitumor immunity in mouse tumor cell lines

Azioni biochim/fisiol

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations.

Caratteristiche e vantaggi

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Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H340,H350,H360FD
• Consigli di prudenza: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 1A
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges