C0551
Monoclonal Anti-CD11b antibody produced in mouse
clone ICRF44, purified immunoglobulin, buffered aqueous solution
Sinonimo/i:
Monoclonal Anti-CD11b
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
ICRF44, monoclonal
Stato
buffered aqueous solution
PM
antigen 165-170 kDa
Reattività contro le specie
human
tecniche
flow cytometry: 5 μL using 1 × 106 cells
Isotipo
IgG1
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
2-8°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... ITGAM(3684)
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Descrizione generale
CD11b is also known as Mac-1, CR3, MO-1 and C3bi receptor. It belongs to β 2 integrin family. The gene encodes the integrin α M chain. It is expressed on the surface of circulating monocytes, granulocytes, neutrophils, macrophages, dendritic cells and certain NK cells. It is present in subcellular granules in granulocytes and on subsets of macrophages.
Monoclonal anti-Human CD11b antibody (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human monocytes.
Specificità
Recognizes the CD11b α-chain of the human CD11b/CD18 complex. The antibody is useful for studies on cell adhesion and migration and for the detection of leukocyte adhesion deficiencies. It may be used to stain acetone-fixed cryostat sections or cell preparations. The epitope recognized by the antibody is formalin sensitive.
2nd Workshop: code no. M104
3rd Workshop: code no. 202 and 238
4th Workshop: code no. M47
2nd Workshop: code no. M104
3rd Workshop: code no. 202 and 238
4th Workshop: code no. M47
Immunogeno
human monocytes.
Applicazioni
Monoclonal Anti-CD11b antibody produced in mouse has been used in immunostaining and flow cytometry.
Azioni biochim/fisiol
CD11b/CD18 acts as a receptor for C3bi, clotting factor X, fibrinogen and ICAM-1. It is involved in cell-cell and cell-substrate interactions. It plays a crucial role in several immunological processes as well including leukocyte extravasation and phagocytosis. It also plays an important role in certain coagulation protease cascade and in cell migration.
Descrizione del bersaglio
CD11b α-chain of the human CD11b/CD18 complex is an α/β heterodimeric glycoprotein which belongs to the β2 integrin family. It is also known as Mac-1, CR3, MO-1 and C3bi receptor. CD11b is expressed on the surface of circulating monocytes, granulocytes and certain NK cells and is also present in subsets of macrophages. It functions as a receptor for iC3b, clotting factor X, fibrinogen and ICAM-1.
Stato fisico
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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L Knopfova et al.
Neoplasma, 55(4), 286-293 (2008-05-29)
The c-myb protooncogene as well as its transforming derivate, the v-myb oncogene code for transcription factors. They regulate transcription of specific target genes thus controlling proliferation, differentiation and apoptosis of hematopoietic cells. Up-regulation of the c-myb expression or rearrangement/amplification of
Liliane Fossati-Jimack et al.
PloS one, 8(2), e57082-e57082 (2013-03-02)
The CD11b/CD18 integrin (complement receptor 3, CR3) is a surface receptor on monocytes, neutrophils, macrophages and dendritic cells that plays a crucial role in several immunological processes including leukocyte extravasation and phagocytosis. The minor allele of a non-synonymous CR3 polymorphism
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