B7880

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt

≥97% (HPLC), powder

• Sinonimo/i: 8-Br-cAMP
• Formula empirica (notazione di Hill): C₁₀H₁₀BrN₅NaO₆P
• Numero CAS: 76939-46-3
• Peso molecolare: 430.08
• Beilstein: 7739743
• Numero MDL: MFCD00005844
• Codice UNSPSC: 41106305
• ID PubChem: 24278020
• NACRES: NA.77

Proprietà

• Saggio: ≥97% (HPLC)
• Stato: powder
• Colore: off-white
• Solubilità: H₂O: 100 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: [Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Br)nc12
• InChI: 1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1; DMRMZQATXPQOTP-GWTDSMLYSA-M

Descrizione

Descrizione generale

8-Bromoadenosine 3′:5′-cyclic monophosphate is a brominated cyclic mononucleotide.

Applicazioni

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt has been used:

• to study its effect on fas and caspase-3 mRNA expression and on P4 production in bovine mid luteal cell culture
• used to treat choriocarcinoma BeWo cell line and study its effect on cell viability, apoptosis and morphological changes in the nuclei
• in superfusion medium for head kidneys stimulation

Azioni biochim/fisiol

Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

Cell-permeable cAMP analog with greater resistance to hydrolysis by phosphodiesterases than cAMP.

Caratteristiche e vantaggi

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Altre note

Membrane-permeable cAMP analog.

Avvertenza

Sensitive to light and moisture.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)