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Merck
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Documenti fondamentali

B0189

Sigma-Aldrich

Casticin

from Vitex trifolia, ≥98% (HPLC)

Sinonimo/i:

Casticine, Quercetagetin 3,6,7,4′-tetramethyl ether, Vitexicarpin

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About This Item

Formula empirica (notazione di Hill):
C19H18O8
Numero CAS:
479-91-4
Peso molecolare:
374.34
Codice UNSPSC:
12352200
NACRES:
NA.25

Origine biologica

Vitex trifolia

Saggio

≥98% (HPLC)

Stato

powder

Solubilità

ethanol: 1 mg/mL, clear, colorless to light yellow

applicazioni

metabolomics
vitamins, nutraceuticals, and natural products

Temperatura di conservazione

2-8°C

InChI

1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3
PJQLSMYMOKWUJG-UHFFFAOYSA-N

Descrizione generale

Casticin is one of the flavonoids present in the traditional Chinese medicine Inula japonica Thunb. It is a polymethyl compound with three rings, a catechol moiety at ortho position, one double bond, two hydroxyl groups, and four methoxy groups. It has been isolated from the fruits, seeds, and leaves of various Vitex species.

Applicazioni

Casticin from Vitex trifolia is used to study its mechanisms of action as an antiiflammatory and anticancer agent via processes such as TRAIL-induced apoptosis, cell cycle arrest, ROS generation, and glutathione (GSH) depletion.

Azioni biochim/fisiol

Casticin has anticancer, pro-apoptotic, anti-proliferative, anti-asthmatic, and anti-angiogenic properties. In addition, it exhibits anti-inflammatory behavior by means of its inhibitory effect on lipoxygenases and T- & B-lymphocytes. Due to its oestrogenic activity, it is being used to manage Premenstrual syndrome in women. It is also reported to mitigate rheumatoid arthritis and liver fibrosis manifestations.
Tubulin-binding anticancer flavonoid. Casticin induces apoptosis in cancer cells.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
SLBC2037V

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Lihua He et al.
Oncology reports, 29(1), 103-108 (2012-10-16)
Casticin, a polymethoxyflavone, has been reported to exert anticancer activities. The objectives of this study were to examine the molecular mechanisms by which casticin induces the growth inhibition and cell cycle arrest in human hepatocellular carcinoma (HCC) cells. The HCC
Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells.
Tang SY, Zhong MZ, Yuan GJ, et al.
Oncology Reports (2012)
So Min Lee et al.
Inflammation, 35(2), 584-593 (2011-05-27)
Pro-inflammatory cytokines induce injury of endothelial cells caused by increases of adhesion molecules, leading to vascular inflammation and the development of atherosclerosis. Recent pharmacological studies have demonstrated that vitexicarpin, a flavonoid isolated from Vitex rotundifolia, has anti-inflammatory, antitumor, and analgesic
Duck-jae Koh et al.
Journal of ethnopharmacology, 136(3), 399-405 (2011-01-22)
The fruits of Vitex rotundifolia L. have long been used for the treatment of inflammation of the respiratory tract in East Asia. To determine if casticin, one of the constituents of Vitex rotundifolia L., has anti-allergic and anti-inflammatory effects in
Yun Ling et al.
Biomedical chromatography : BMC, 26(12), 1502-1508 (2012-03-13)
Casticin (3',5-dihydroxy-3, 4',6,7-tetramethoxyflavone) has been revealed to possess various kinds of pharmacological activities, including immunomodulatory, anti-hyperprolactinemia, anti-tumor and neuroprotetective activities. In order to gain an understanding of the biotransformation of casticin in vivo, a systematic method based on liquid chromatography-electrospray
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