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Merck
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Key Documents

AV48140

Sigma-Aldrich

Anti-PGK1 (AB1) antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Anti-MGC117307, Anti-MGC142128, Anti-MGC8947, Anti-MIG10, Anti-PGKA, Anti-Phosphoglycerate kinase 1

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

44 kDa

Reattività contro le specie

horse, sheep, bovine, rat, human, guinea pig, dog, mouse, rabbit

Concentrazione

0.5 mg - 1 mg/mL

tecniche

western blot: suitable

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... PGK1(5230)

Categorie correlate

Descrizione generale

Phosphoglycerate kinase 1 (PGK1) is an enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate during glycolysis. PGK1 expression has been correlated to CXCR4 expression, survival and bone marrow metastasis in neuroblastoma patients.
Rabbit Anti-PGK1 antibody recognizes bovine, human, mouse, rat, and canine PGK1.

Immunogeno

Synthetic peptide directed towards the N terminal region of human PGK1

Applicazioni

Rabbit Anti-PGK1 antibody has been used as a loading control in immunoblotting assays. The product is suitable at a concentration of 0.5μg/ml for western blots.

Azioni biochim/fisiol

PGK1 is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The protein may also act as a cofactor for polymerase alpha.The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. A pseudogene of this gene has been found on the X-chromosome and another on chromosome 19. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. A pseudogene of this gene has been found on the X-chromosome and another on chromosome 19. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Sequenza

Synthetic peptide located within the following region: PEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFR

Stato fisico

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Alice Y Wang et al.
Molecular and cellular biology, 31(18), 3871-3884 (2011-07-28)
The incorporation of histone variants into nucleosomes represents one way of altering the chromatin structure to accommodate diverse functions. Histone variant H2A.Z has specific roles in gene regulation, heterochromatin boundary formation, and genomic integrity. The precise features required for H2A.Z
Helen M Ameis et al.
PloS one, 8(12), e83701-e83701 (2014-01-01)
A close relationship between phosphoglycerate kinase 1 (PGK1) and the CXCR4/SDF1 axis (chemokine receptor 4/stromal cell derived factor 1) has been shown for several cancers. However, the role of PGK1 has not been investigated for neuroblastoma, and PGK1 might be

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