A8937

Adenosine 5′-triphosphate dipotassium salt hydrate

from microbial, ≥92% (HPLC)

• Sinonimo/i: ATP, 5′-ATP-K₂
• Formula empirica (notazione di Hill): C₁₀H₁₄K₂N₅O₁₃P₃ · xH₂O
• Numero CAS: 42373-41-1
• Peso molecolare: 583.36 (anhydrous basis)
• Numero MDL: MFCD00084672
• Codice UNSPSC: 41106305
• eCl@ss: 32160414
• ID PubChem: 24891383
• NACRES: NA.51

Proprietà

• Origine biologica: microbial
• Livello qualitativo: 200
• Saggio: ≥92% (HPLC)
• Stato: powder
• Solubilità: H₂O: 50 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: [K+].[K+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C10H16N5O13P3.2K/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1; YFPSRAQDZYNYPX-IDIVVRGQSA-L

Descrizione

Descrizione generale

Adenosine 5′-triphosphate (ATP) is synthesized in mitochondria by oxidative phosphorylation.

Applicazioni

Adenosine 5′-triphosphate dipotassium salt hydrate has been used:

• in in vitro transcription reaction as nucleotide source and in 2x RNA binding buffer
• as a component of energy solution for calibrating crude cell extract
• to test its dependency with PK11195 in mediating autophagy

Azioni biochim/fisiol

Adenosine 5′-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is used in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. Metabolic disorders lead to ATP deficiency. Use of xanthine oxidoreductase inhibitors and inosine improves intracellular ATP levels.

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems.

Avvertenza

For maximum stability, store as frozen solution at pH 3.5 to 6.8.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves