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Key Documents

A2487

Sigma-Aldrich

Cotrimoxazole, Ready Made Solution

100 mg/mL in DMSO

Sinonimo/i:

Trimethoprim-Sulfamethoxazole, TMP-SMX

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About This Item

Formula empirica (notazione di Hill):
C14H18N4O3 · 5 C10H11N3O3S
Numero CAS:
8064-90-2
Peso molecolare:
1556.71
Codice UNSPSC:
51102829
NACRES:
NA.85

Forma fisica

liquid

Livello qualitativo

200

Concentrazione

100 mg/mL in DMSO

Colore

colorless to faint yellow

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria
fungi
parasites

Modalità d’azione

DNA synthesis | interferes

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

InChI

1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)
WZRJTRPJURQBRM-UHFFFAOYSA-N

Applicazioni

Cotrimoxazole has been used as an antimicrobial agent.

Azioni biochim/fisiol

Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.

Confezionamento

1ml

Nota sulla preparazione

prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

Altre note

Keep container tightly closed in a dry and well-ventilated place.

Pittogrammi

Health hazard
GHS08

Avvertenze

Warning

Indicazioni di pericolo

H361fd,H412

Classi di pericolo

Aquatic Chronic 3 - Repr. 2

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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