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Key Documents

51060

Sigma-Aldrich

Guanosine 5′-diphosphate disodium salt

≥90% (HPLC)

Sinonimo/i:

5′-GDP-Na2

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About This Item

Formula empirica (notazione di Hill):
C10H13N5Na2O11P2
Numero CAS:
Peso molecolare:
487.16
Numero CE:
Numero MDL:
Codice UNSPSC:
41106305
ID PubChem:
NACRES:
NA.51

Origine biologica

Porcine brain
microbial (Corynebacterium sp)
synthetic

Saggio

≥90% (HPLC)

Forma fisica

powder

Solubilità

H2O: 50 mg/mL, clear, colorless

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H15N5O11P2.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1
LTZCGDIGAHOTKN-LGVAUZIVSA-L

Descrizione generale

Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine. GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells.

Applicazioni

Guanosine 5′-diphosphate (GDP) is used as a substrate of pyruvate kinase to produce GTP in support of RNA biosyntheis. GDP is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). GDP is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.
Guanosine 5′-diphosphate disodium salt has been used:
  • in fluorescent metal nanoclusters selectivity of guanosine 3′-diphosphate-5′-di(tri)phosphate, ppGpp
  • in screening of fluorescence emission of hypocrellin A-zinc complex
  • as a component of assay buffers in the autoradiography of mice brain sections

Azioni biochim/fisiol

Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors. Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein . G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP. GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI).

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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Biosensors And Bioelectronics, 49, 433-437 (2013)
Perinatal vs genetic programming of serotonin states associated with anxiety
Altieri SC, et al.
Neuropsychopharmacology, 40(6), 1456-1456 (2015)
Guanosine phosphate binding protein coupled receptors in prostate cancer: a review
Raj GV, et al.
The Journal of Urology, 167(3), 1458-1463 (2002)
Guanosine behind the scene
Ciruela, Francisco
Journal of Neurochemistry, 126(4), 425-427 (2013)
Michael P East et al.
Seminars in cell & developmental biology, 22(1), 3-9 (2010-07-20)
Arf GAPs (ADP-ribosylation factor GTPase-activating proteins) are essential components of Arf (ADP-ribosylation factor) signaling pathways. Arf GAPs stimulate the hydrolysis of GTP to GDP to transition Arf from the active, GTP bound, state to the inactive, GDP bound, state. Based

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