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23120

Sigma-Aldrich

α-Chloralose

≥98.0% (chloralose, AT)

Sinonimo/i:

1,2-O-(2,2,2-Trichloroethylidene)-α-D-glucofuranose, Anhydro-D-glucochloral, Chloralose

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About This Item

Formula empirica (notazione di Hill):
C8H11Cl3O6
Numero CAS:
15879-93-3
Peso molecolare:
309.53
Beilstein:
85418
Numero CE:
240-016-7
Numero MDL:
MFCD00005542
Codice UNSPSC:
12352201
ID PubChem:
57648022
NACRES:
NA.21

Saggio

≥98.0% (chloralose, AT)

Forma fisica

powder

Attività ottica

[α]20/D +17±2°, 5 hr, c = 2% in ethanol

Impurezze

15% Beta-chloralose

Punto di fusione

178-184 °C

Solubilità

water: soluble 1 gm in 225 ml at 15 °C
chloroform: slightly soluble
diethyl ether: soluble
glacial acetic acid: soluble
petroleum ether: insoluble

Stringa SMILE

OC[C@@H](O)[C@H]1O[C@@H]2O[C@@H](O[C@@H]2[C@H]1O)C(Cl)(Cl)Cl

InChI

1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1
OJYGBLRPYBAHRT-IPQSZEQASA-N

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Azioni biochim/fisiol

α-Chloralose stimulates the gama-aminobutyric acid (GABA)-induced chloride conductance of gama-aminobutyric acidA (GABAA) receptors expressed in Xenopus laevis oocytes.

Componenti

mixture of isomers of ~85% α-chloralose; ~15% β-chloralose

Altre note

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Pittogrammi

Skull and crossbonesEnvironment
GHS06,GHS09

Avvertenze

Danger

Indicazioni di pericolo

H301,H332,H336,H410

Classi di pericolo

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 3

Organi bersaglio

Central nervous system

Codice della classe di stoccaggio

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

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R W Gear et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(16), 7175-7181 (1999-08-06)
We tested the hypothesis that noxious stimuli induce pain modulation by activation of supraspinal structures. We found that intense noxious stimuli (i.e., subdermal injection of capsaicin or paw immersion in hot water) induced profound attenuation of the jaw-opening reflex in
K M Garrett et al.
The Journal of pharmacology and experimental therapeutics, 285(2), 680-686 (1998-05-15)
alpha-Chloralose is widely used as an anesthetic in the laboratory due to its minimal effects on autonomic and cardiovascular systems, yet little is known about its mechanism of action. We examined the effects of alpha-chloralose on gamma-aminobutyric acid type A
Mingming Zhu et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 179(6), 701-710 (2009-03-12)
Direct measurements of deep-brain and body-core temperature were performed on rats to determine the influence of cerebral blood flow (CBF) on brain temperature regulation under static and dynamic conditions. Static changes of CBF were achieved using different anesthetics (chloral hydrate
Hongxia Lei et al.
Journal of neuroscience research, 88(2), 413-419 (2009-09-12)
Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the case of (1)H
Renata F Leoni et al.
NeuroImage, 58(1), 75-81 (2011-06-29)
Hypertension afflicts 25% of the general population and over 50% of the elderly. In the present work, arterial spin labeling MRI was used to non-invasively quantify regional cerebral blood flow (CBF), cerebrovascular resistance and CO(2) reactivity in spontaneously hypertensive rats
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