22640

Quinine hemisulfate salt monohydrate

BioReagent, suitable for fluorescence, 99.0-101.0%

• Sinonimo/i: Quinine sulfate (2:1) (salt) dihydrate
• Formula empirica (notazione di Hill): C₂₀H₂₄N₂O₂ · 0.5H₂O₄S · H₂O
• Numero CAS: 207671-44-1
• Peso molecolare: 391.47
• Beilstein: 6113937
• Numero MDL: MFCD00150790
• Codice UNSPSC: 12352210
• ID PubChem: 329752330
• NACRES: NA.32

Proprietà

• Nome Commerciale: BioReagent
• Saggio: 99.0-101.0%
• Punto di fusione: ~225 °C (dec.) (lit.)
• Fluorescenza: λ_ex 347 nm; λ_em 448 nm in 0.5 M sulfuric acid
• Compatibilità: suitable for fluorescence
• Spettro attività antibiotica: parasites
• Modalità d’azione: enzyme | inhibits
• Stringa SMILE: O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5
• InChI: 1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1; ZHNFLHYOFXQIOW-LPYZJUEESA-N

Descrizione

Descrizione generale

Quinine hemisulfate salt monohydrate is a naturally occurring well known fluorescent standard material. Quinine hemisulfate salt monohydrate or QSM has a fluorescence lifetime between 1.0 to 3.0 ns.

Applicazioni

Quinine hemisulfate salt monohydrate is used for indirect photometric detection of polyamines in biological samples. It is suitable for studying metabolism of bio crystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

Azioni biochim/fisiol

Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves