18887
Byzen Pro™ Protein A resin
suitable for affinity chromatography
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About This Item
Codice UNSPSC:
13111000
NACRES:
NA.56
Prodotti consigliati
Forma fisica
suspension
Livello qualitativo
tecniche
affinity chromatography: suitable
Dimens. media particelle
70 μm
Temperatura di conservazione
2-8°C
Applicazioni
Byzen Pro™ Protein A resin is an affinity chromatography medium in which a novel Protein A mutant is used as a ligand. Conventional protein A resins use strongly acidic buffers to elute antibodies, exposing the target antibody to the risks of aggregation and decreased activities. In contrast, this temperature- responding Byzen Pro™ Protein A resin allows antibodies to be eluted under neutral pH by a simple temperature change. This eliminates any risk of aggregation and decreased activity of the antibody, improving manufacturing efficiency for pharmaceutical antibodies.
Caratteristiche e vantaggi
Typical Product Profile:
Bead Structure, Cross-linked polyvinyl alcohol, Mean Particle Size 70 μm, Max. Back Pressure 0.3 MPa, Flow Rate (Recommended) 125-250 cm/h, pH Range (Recommended) pH 6-8, Ligand: Recombinant Protein A mutant, Ligand Immobilization: Multiple ligation, Dynamic Binding Capacity (20 cm column): 26 g/L (250 cm/h) 34 g/L (125 cm/h), Total Binding Capacity 40 g/L, Binding Temperature Below 10°C, Eluting Temperature 37 to 40°C, Mode of Temperature Change: Conventional heat exchange system can be used.
Bead Structure, Cross-linked polyvinyl alcohol, Mean Particle Size 70 μm, Max. Back Pressure 0.3 MPa, Flow Rate (Recommended) 125-250 cm/h, pH Range (Recommended) pH 6-8, Ligand: Recombinant Protein A mutant, Ligand Immobilization: Multiple ligation, Dynamic Binding Capacity (20 cm column): 26 g/L (250 cm/h) 34 g/L (125 cm/h), Total Binding Capacity 40 g/L, Binding Temperature Below 10°C, Eluting Temperature 37 to 40°C, Mode of Temperature Change: Conventional heat exchange system can be used.
Note legali
Byzen Pro is a trademark of Nomadic Bioscience Co., Ltd
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Ichiro Koguma et al.
Journal of chromatography. A, 1305, 149-153 (2013-07-31)
We attempted to evaluate a novel purification method of immunoglobulins (IgGs) by using a mutant type of protein A. Although this mutant protein A binds to IgGs at 5°C, the IgGs are released at 40°C; hence, it was designated as
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