Y0001761

Nicorandil

European Pharmacopoeia (EP) Reference Standard

• Sinonimo/i: 2-(Pyridine-3-carbonylamino)ethyl nitrate, 2-Nicotinamidoethyl nitrate, Ikorel, N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide, SG-75, Sigmart, Zynicor
• Formula empirica (notazione di Hill): C₈H₉N₃O₄
• Numero CAS: 65141-46-0
• Peso molecolare: 211.17
• Numero MDL: MFCD00186520
• Codice UNSPSC: 41116107
• ID PubChem: 329831558
• NACRES: NA.24

Proprietà

• Grado: pharmaceutical primary standard
• Famiglia di API: nicorandil
• Produttore/marchio commerciale: EDQM
• applicazioni: pharmaceutical (small molecule)
• Formato: neat
• Temperatura di conservazione: −20°C
• Stringa SMILE: [O-][N+](=O)OCCNC(=O)c1cccnc1
• InChI: 1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12); LBHIOVVIQHSOQN-UHFFFAOYSA-N

Descrizione

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Nicorandil EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Azioni biochim/fisiol

Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor.

Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H242,H302
• Consigli di prudenza: P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410
• Classi di pericolo: Acute Tox. 4 Oral - Org. Perox. D
• Codice della classe di stoccaggio: 5.2 - Organic peroxides and self-reacting hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable