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P3700000

Propylthiouracil

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

6-Propyl-2-thiouracil, 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone, 4-Hydroxy-2-mercapto-6-propylpyrimidine

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About This Item

Formula empirica (notazione di Hill):
C7H10N2OS
Numero CAS:
51-52-5
Peso molecolare:
170.23
Beilstein:
130039
Numero MDL:
MFCD00006041
Codice UNSPSC:
41116107
ID PubChem:
329820187
NACRES:
NA.24

Grado

pharmaceutical primary standard

Descrizione

enzyme inhibitor

Famiglia di API

propylthiouracil

Produttore/marchio commerciale

EDQM

Punto di fusione

218-220 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

CCCC1=CC(=O)NC(=S)N1

InChI

1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
KNAHARQHSZJURB-UHFFFAOYSA-N

Informazioni sul gene

human ... DIO1(1733) , TPO(7173)

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Categorie correlate

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Propylthiouracil EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H351

Classi di pericolo

Acute Tox. 4 Oral - Carc. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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L-Thyroxine ≥98% (HPLC)

Sigma-Aldrich

T2376

L-Thyroxine

Eleni Memi et al.
Journal of pediatric endocrinology & metabolism : JPEM, 25(3-4), 331-343 (2012-07-10)
Antithyroid drugs (ATDs) have been widely and effectively used for the treatment of pediatric and adult thyrotoxicosis for more than a half century. Since the very beginning of ATD use, reports of hepatic dysfunction related to propylthiouracil (PTU) therapy have
Spiros Karras et al.
Journal of pediatric endocrinology & metabolism : JPEM, 25(7-8), 623-630 (2012-11-20)
Propylthiouracil (PTU), carbimazole (CMZ) and methimazole (MMI) are the most common drugs used today in cases of adolescent thyrotoxicosis. Skepticism has been growing regarding the use of PTU in childhood and its association with severe liver failure. The aim of
Daniel Glinoer et al.
Current opinion in endocrinology, diabetes, and obesity, 19(5), 402-407 (2012-07-24)
To bring to the attention of healthcare professionals the additional information on propylthiouracil (PTU)-related hepatotoxicity, based on a reanalysis of medical files reported to the Food and Drug Administration (1982-2008) for acute liver failure in PTU-treated hyperthyroid patients, and propose
Long-term propylthiouracil use and acute myeloid leukemia: a case report and review of the literature.
Daniele Focosi et al.
Annals of hematology, 87(3), 233-235 (2007-09-12)
A Rambaldi et al.
Liver, 21(6), 398-404 (2002-03-21)
The aim of this review was to determine the benefits and adverse effects of propylthiouracil for patients with alcoholic liver disease. Systematic Cochrane Review of randomised clinical trials. The Cochrane Hepato-Biliary Controlled Clinical Trials Register, The Cochrane Library, MEDLINE, and
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