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G0325000

Glibenclamide

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

5-cloro-N-[4-(cicloesilureidosolfonil)fenetil]-2-metossibenzamide, Gliburide, N-p-[2-(5-cloro-2-metossibenzamido)etil]benzenesolfonil-N′-cicloesilurea

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About This Item

Formula empirica (notazione di Hill):
C23H28ClN3O5S
Numero CAS:
10238-21-8
Peso molecolare:
494.00
Numero MDL:
MFCD00056625
Codice UNSPSC:
41116107
ID PubChem:
329799806
NACRES:
NA.24

Grado

pharmaceutical primary standard

Famiglia di API

glybenclamide

Produttore/marchio commerciale

EDQM

applicazioni

pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3

InChI

1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
ZNNLBTZKUZBEKO-UHFFFAOYSA-N

Informazioni sul gene

human ... ABCC8(6833) , KCNJ11(3767)

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Categorie correlate

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Glybenclamide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Indicazioni di pericolo

H413

Consigli di prudenza

P273 - P501

Classi di pericolo

Aquatic Chronic 4

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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Kevin N Sheth
Stroke, 44(6 Suppl 1), S136-S136 (2013-06-05)
Ruoyu Wang et al.
Journal of separation science, 36(6), 1015-1021 (2013-02-19)
In this paper, the novel surface molecularly imprinted polymers based on dendritic-grafting magnetic nanoparticles were developed to enrich and separate glibenclamide in health foods. The density functional theory method was used to give theoretical directions to the synthesis of molecularly
Kevin N Sheth et al.
Stroke, 45(1), 281-283 (2013-11-07)
Preclinical and retrospective clinical data indicate that glyburide, a selective inhibitor of sulfonylurea receptor 1-transient receptor potential melastatin 4, is effective in preventing edema and improving outcome after focal ischemia. We assessed the feasibility of recruiting and treating patients with
Mariel Núñez et al.
BMC pharmacology & toxicology, 14, 6-6 (2013-01-15)
Glibenclamide (Gli) binds to the sulphonylurea receptor (SUR) that is a regulatory subunit of ATP-sensitive potassium channels (KATP channels). Binding of Gli to SUR produces the closure of KATP channels and the inhibition of their activity. This drug is widely
Nagaraj Kerur et al.
Investigative ophthalmology & visual science, 54(12), 7395-7401 (2013-10-12)
Accumulation of Alu RNA transcripts due to DICER1 deficiency in the retinal pigmented epithelium (RPE) promotes geographic atrophy. Recently we showed that Alu RNA activated the NLRP3 inflammasome, leading to RPE cell death via interleukin-18 (IL-18)-mediated MyD88 signaling. However, the
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