BP227

Metformin hydrochloride

British Pharmacopoeia (BP) Reference Standard

• Sinonimo/i: 1,1-Dimethylbiguanide hydrochloride, Metformin
• Formula condensata: NH₂C(=NH)NHC(=NH)N(CH₃)₂ · HCl
• Numero CAS: 1115-70-4
• Peso molecolare: 165.62
• Numero CE: 214-230-6
• Numero MDL: MFCD00012582
• Codice UNSPSC: 41116107
• NACRES: NA.24

Proprietà

• Grado: pharmaceutical primary standard
• Famiglia di API: metformin
• Forma fisica: crystalline
• Durata: limited shelf life, expiry date on the label
• Produttore/marchio commerciale: BP
• Punto di fusione: 223-226 °C (lit.)
• applicazioni: pharmaceutical; pharmaceutical small molecule
• Formato: neat
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Cl[H].CN(C)C(=N)NC(N)=N
• InChI: 1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H; OETHQSJEHLVLGH-UHFFFAOYSA-N

Descrizione

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Metformin hydrochloride BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Metformin Tablets

Metformin Oral Solution

Metformin and Sitagliptin Prolonged-release Tablets

Metformin Prolonged-release Tablets

Metformin and Sitagliptin Tablets

Azioni biochim/fisiol

Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

Confezionamento

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Altre note

Sales restrictions may apply.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H319
• Consigli di prudenza: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable