74601

3,3′-Diindolylmethane

analytical standard

• Sinonimo/i: DIM
• Formula empirica (notazione di Hill): C₁₇H₁₄N₂
• Numero CAS: 1968-05-4
• Peso molecolare: 246.31
• Numero MDL: MFCD00195766
• Codice UNSPSC: 41116107
• NACRES: NA.24

Proprietà

• Grado: analytical standard
• Livello qualitativo: 100
• Saggio: ≥97.5% (HPLC)
• Durata: limited shelf life, expiry date on the label
• applicazioni: food and beverages
• Formato: neat
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: C(c1c[nH]c2ccccc12)c3c[nH]c4ccccc34
• InChI: 1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2; VFTRKSBEFQDZKX-UHFFFAOYSA-N

Descrizione

Descrizione generale

3,3′-Diindolylmethane, a dimer of indole-3-carbinol, is a component of cruciferous vegetables. It is known to exhibit anticancer effects.

Applicazioni

3,3′-Diindolylmethane may be used as a model substrate to analyze the role of 3,3′-diindolylmethane in inducing apoptosis in human cancer cells.

Azioni biochim/fisiol

Acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol. It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells. DIM induces a G₁ cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H⁺-ATPase inhibitor. The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system.

Prodotti consigliati

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Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335,H413
• Consigli di prudenza: P273 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable