43107

Vitamina B₁₂

tested according to Ph. Eur.

• Sinonimo/i: α-(5,6-dimetilbenzimidazolil)cianocobamide, CN-Cbl, Cianocob(III)alamina, Cianocobalamina
• Formula empirica (notazione di Hill): C₆₃H₈₈CoN₁₄O₁₄P
• Numero CAS: 68-19-9
• Peso molecolare: 1355.37
• Beilstein: 4122889
• Numero CE: 200-680-0
• Numero MDL: MFCD00151092
• Codice UNSPSC: 12352205
• ID PubChem: 329756307
• NACRES: NA.21

Proprietà

• Origine biologica: fermentation/recombinant
• Livello qualitativo: 100
• agenzia: USP/NF; tested according to Ph. Eur.
• Saggio: 96.0-102.0% dry basis
• Stato: powder
• Colore: dark red
• Solubilità: water: soluble 1 gm in 80 ml; acetone: insoluble; alcohol: soluble; chloroform: insoluble; diethyl ether: insoluble
• applicazioni: cell analysis
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@
• InChI: 1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1; RMRCNWBMXRMIRW-QJRSUKKJSA-L

Descrizione

Descrizione generale

Cyanocobalamin, also referred to as Vitamin B₁₂, is a water soluble vitamin.

Applicazioni

Cyanocobalamin was added in the assay buffer during the analysis step of ELISA for ensuring that all transcobalamin was saturated with cobalamin before analysis. Cyanocobalamin was also used for examining its impact on the expression of mPer1 and mPer2 in vivo.

Azioni biochim/fisiol

Cyanocobalamin plays a role in functioning of brain and nervous system. It is also involved in hematopoiesis. Vitamin B₁₂ deficiency leads to megaloblastic anemia. It is also associated with irreversible nervous system breakdown leading to spinal cord degeneration.

Cyanocobalamin refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. Cyanocobalamin along with other B vitamins thiamine (B1) and pyridoxine (B6) blocks the thermal hyperalgesia in rats with neuropathic pain caused by spinal ganglia compression (CCD) or loose ligation of the sciatic nerve (CCI). It can stimulate the anaerobic biodegradation of chloroform.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)