20801

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate

meets analytical specification of Ph. Eur., BP, NF, 98-100.5% (calc with ref. to anhyd. subst.)

• Sinonimo/i: β,β,β-Trichloro-tert-butyl alcohol hemihydrate, ‘Acetone chloroform’, ‘Chlorobutanol’
• Formula condensata: Cl₃CC(CH₃)₂OH · 0.5H₂O
• Numero CAS: 6001-64-5
• Peso molecolare: 186.46
• Beilstein: 878167
• Numero CE: 249-042-3
• Numero MDL: MFCD02179352
• Codice UNSPSC: 41116107
• ID PubChem: 57647873
• NACRES: NA.21

Proprietà

• Livello qualitativo: 200
• Saggio: 98-100.5% (calc with ref. to anhyd. subst.)
• Stato: solid
• Qualità: meets analytical specification of Ph. Eur., BP, NF
• Impurezze: ≤0.002% heavy metals (as Pb); 4.5-5.5% water (Karl Fischer)
• Residuo alla calcinazione: ≤0.1% (as SO₄)
• Punto di fusione: 76-80 °C
• Anioni in tracce: chloride (Cl^-): ≤100 mg/kg
• applicazioni: pharmaceutical (small molecule)
• Stringa SMILE: O.CC(C)(O)C(Cl)(Cl)Cl.CC(C)(O)C(Cl)(Cl)Cl
• InChI: 1S/2C4H7Cl3O.H2O/c2*1-3(2,8)4(5,6)7;/h2*8H,1-2H3;1H2; WRWLCXJYIMRJIN-UHFFFAOYSA-N

Descrizione

Applicazioni

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) is a preservative used as a standard for quantifying preservatives in pharmaceutical formulations by using capillary electrophoretic method. It has also been used to anesthetize leeches for preparing c-DNA library from regenerating retzius cells.

Azioni biochim/fisiol

Chlorobutanol or 1,1,1-Trichloro-2-methyl-2-propanol is a opthalmic preservative and sedative hypnotic that possess antibacterial and antifungal properties. It also decreases the conduction velocity and induces conduction failure and automaticity within isolated ventricular muscle strips as well as impacts myocardial cells by acting on cell membrane and reduces isometric tension produced by heart.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 212.0 °F - closed cup
• Punto d’infiammabilità (°C): 100 °C - closed cup
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves