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14131

Supelco

Iopanoic acid

analytical standard

Sinonimo/i:

2-(3-Amino-2,4,6-triiodobenzyl)butyric acid, 3-(3-Amino-2,4,6-triiodophenyl)-2-ethylpropanoic acid, Iodopanoic acid

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About This Item

Formula empirica (notazione di Hill):
C11H12I3NO2
Numero CAS:
96-83-3
Peso molecolare:
570.93
Numero CE:
202-539-9
Numero MDL:
MFCD00038687
Codice UNSPSC:
41116107
ID PubChem:
329750405

Grado

analytical standard

Livello qualitativo

100

Saggio

≥95.0% (HPLC)

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

150-156 °C

applicazioni

clinical

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C(O)C(CC)CC1=C(I)C(N)=C(I)C=C1I

InChI

1S/C11H12I3NO2/c1-2-5(11(16)17)3-6-7(12)4-8(13)10(15)9(6)14/h4-5H,2-3,15H2,1H3,(H,16,17)
OIRFJRBSRORBCM-UHFFFAOYSA-N

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Descrizione generale

Iopanoic acid is an oral cholecystographic agent, which is rich in iodine and is a potent inhibitor of 5′-deiodinase.
This radiographic contrast agent prevents the release of thyroid hormone from the thyroid gland. It also inhibits the conversion of thyroxine to triiodothyronine.

Applicazioni

Iopanoic acid may be used as a standard to investigate the presence and regulation of type 3 iodothyronine deiodinase in human cardiomyocytes.

Prodotti consigliati

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
BCCC6613
BCBV8566
BCBP9737V
BCBP9737

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3,3′,5-Triiodo-L-thyronine ≥95% (HPLC), powder

Sigma-Aldrich

T2877

3,3′,5-Triiodo-L-thyronine

Iopanoic acid rapidly controls type I amiodarone-induced thyrotoxicosis prior to thyroidectomy.
Bogazzi F, et al.
Journal of Endocrinological Investigation, 25(2), 176-180 (2002)
Evidence against a major role of L-thyroxine at the pituitary level: studies in rats treated with iopanoic acid (telepaque).
Obregon JM, et al.
Endocrinology, 106(6), 1827-1836 (1980)
Type 3 iodothyronine deiodinase is expressed in human induced pluripotent stem cell derived cardiomyocytes.
Nishimura K, et al.
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