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11332

Sigma-Aldrich

Atropine sulfate salt monohydrate

tested according to Ph. Eur.

Sinonimo/i:

Atropini sulfas, α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, Tropine tropate

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About This Item

Formula condensata:
(C17H23NO3)2 · H2SO4 · H2O
Numero CAS:
5908-99-6
Peso molecolare:
694.83
Beilstein:
6109275
Numero CE:
200-235-0
Numero MDL:
MFCD00074815
Codice UNSPSC:
12352200
ID PubChem:
329749385
NACRES:
NA.21

agenzia

USP/NF
tested according to Ph. Eur.

Livello qualitativo

200

Punto di fusione

189-192 °C (A) (lit.)

Solubilità

water: soluble 2500 g/L at 4 °C

applicazioni

pharmaceutical (small molecule)

Stringa SMILE

O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6

InChI

1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;
JPKKQJKQTPNWTR-CHYDPLAESA-N

Informazioni sul gene

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131)

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Applicazioni

Atropine sulfate salt monohydrate has been used for anaesthetizing mice for intranasal administration of ropinirole or 7-OH-DPAT.

Azioni biochim/fisiol

Atropine sulfate salt monohydrate is a competitive nonselective antagonist of central and peripheral muscarinic acetylcholine receptors. Atropine is a cholinergic receptor antagonist isolated from Atropa belladona L., Datura stramonium L. and other plants of the solanaceae family. It blocks the ion currents mediated by neuronal nicotinic acetylcholine receptors. Further, it blocks the acetylcholine (ACh)-induced relaxations in human pulmonary veins.
Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H300 + H330

Classi di pericolo

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
BCBZ4813
BCBX1616
BCBW4732
BCBT8628
BCBS9281V

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Chu Lan Lao et al.
Neurotoxicity research, 24(4), 523-531 (2013-07-04)
Parkinson's disease (PD) is a neurodegenerative disease with a hallmark motor defect caused by the death of dopaminergic neurons in the substantia nigra. Intranasal drug administration may be useful for Parkinson's treatment because this route avoids first-pass metabolism and increases
R Zwart et al.
Molecular pharmacology, 52(5), 886-895 (1997-11-14)
Atropine, the classic muscarinic receptor antagonist, inhibits ion currents mediated by neuronal nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. At the holding potential of -80 mV, 1 microM atropine inhibits 1 mM acetylcholine-induced inward currents mediated by rat alpha2beta2
F Trovero et al.
Toxicology and applied pharmacology, 150(2), 321-327 (1998-07-07)
This study consists of two parts, first to compare the pharmacological profile of atropine and CEB-1957 substance toward muscarinic receptor subtypes. In various rat brain structures, binding properties were determined by competition experiments of [3H]pirenzepine, [3H]AF-DX 384, and [3H]4-DAMP in
L Walch et al.
British journal of pharmacology, 130(1), 73-78 (2000-04-26)
1. To characterize the muscarinic receptors on human pulmonary veins associated with the acetylcholine (ACh)-induced relaxation, isolated venous and arterial preparations were pre-contracted with noradrenaline (10 microM) and were subsequently challenged with ACh in the absence or presence of selective
Miklós Palotai et al.
Neurochemical research, 39(8), 1477-1483 (2014-06-05)
The nociceptin/orphanin FQ peptide (NOP) receptor and its endogenous ligand plays role in several physiologic functions of the central nervous system, including pain, locomotion, anxiety and depression, reward and drug addiction, learning and memory. Previous studies demonstrated that the NOP-receptor
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