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Merck
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Documenti fondamentali

MAB5596

Sigma-Aldrich

Anti-HCN2 Antibody

culture supernatant, Chemicon®

Sinonimo/i:

Hyperpolarization-activated and cyclic nucleotide-gated channel 2

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rat

Livello qualitativo

100

Forma dell’anticorpo

culture supernatant

Tipo di anticorpo

primary antibodies

Clone

monoclonal

Reattività contro le specie

mouse, rat

Produttore/marchio commerciale

Chemicon®

tecniche

immunohistochemistry: suitable
western blot: suitable

Isotipo

IgG1

N° accesso NCBI

NM_001194.3

N° accesso UniProt

Q9UL51

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

mouse ... Hcn2(15166)
rat ... Hcn2(114244)

Specificità

HCN2 (Hyperpolarization-activated and cyclic nucleotide-gated channel 2). The antibody recognizes both the glycosyated and deglycosylated form of HCN2. The antibody recognizes a weak band at ~98 kDa and a stronger band at ~108 kDa in glycosylated protein from a retinal membrane preparation.

Immunogeno

Synthetic peptide from rat HCN2.

Applicazioni

Anti-HCN2 Antibody is an antibody against HCN2 for use in IH & WB.
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters
Western blot on rat and mouse retina. The antibody recognizes a weak band at ~98 kDa and a stronger band at ~108 kDa in glycosylated protein from a retinal membrane preparation.

Immunohistochemistry on rat and mouse retina.

Optimal working dilutions must be determined by end user.

Stato fisico

Cultured supernatant containing 0.05% sodium azide.

Stoccaggio e stabilità

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Frank Müller et al.
The European journal of neuroscience, 17(10), 2084-2096 (2003-06-06)
Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels codetermine the integrative behaviour of neurons and shape their response to synaptic stimulation. We used immunohistochemistry and patch-clamp recording to study the composition and distribution of HCN channels in the rat retina. All four
Joon Ha Park et al.
International journal of molecular medicine, 44(5), 1801-1810 (2019-10-02)
Hyperpolarization‑activated cyclic nucleotide‑gated (HCN) channels have been known to participate in the regulation of neuronal excitability, synaptic transmission and long‑term potentiation in the hippocampus. The present study investigated transient ischemia‑induced changes of HCN1 and HCN2 expressions in the Cornu Ammonis
Stuart M Cain et al.
Pflugers Archiv : European journal of physiology, 467(6), 1367-1382 (2014-06-24)
Burst-firing in distinct subsets of thalamic relay (TR) neurons is thought to be a key requirement for the propagation of absence seizures. However, in the well-regarded Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model as yet there has been no

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