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Key Documents

MAB4419A4

Sigma-Aldrich

Anti-OCT-4 [POU5F1] Antibody, clone 7F9.2, Alexa Fluor™ 488 conjugate

clone 7F9.2, from mouse, ALEXA FLUOR™ 488

Sinonimo/i:

POU domain class 5, transcription factor 1, Octamer-binding protein 3, Oct-3, Octamer-binding protein 4, Oct-4, Octamer-binding transcription factor 3, OTF-3

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

100

Coniugato

ALEXA FLUOR™ 488

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

7F9.2, monoclonal

Reattività contro le specie

mouse, human

tecniche

immunocytochemistry: suitable

Isotipo

IgG1

N° accesso NCBI

NP_038661

N° accesso UniProt

P20263

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... POU5F1(5460)
mouse ... Pou5F1(18999)

Descrizione generale

Octamer-4 (Oct-4), a member of the POU family of transcription factors, has been demonstrated to be vital for the formation of self-renewing pluripotent stem cells. During embryogenesis, expression of Oct-4 is limited to pluripotent cells of the inner cell mass (ICM) that contribute to the formation of all fetal cell types. This relationship between Oct-4 and pluripotency has seen this transcription factor emerge as a marker of pluripotent stem cells. Undifferentiated human and murine pluripotent Embryonic Stem (ES) and Embryonic Carcinoma (EC) cells express Oct-4. Additionally, murine Embryonic Germ (EG) cells are also known to express Oct-4. Following stem cell differentiation, the level of Oct-4 expression decreases. Oct-4 has been identified as one of the main transcription factors required to reprogram somatic cells into induced pluripotent stem cells (iPS cells).

Applicazioni

Anti-OCT-4 [POU5F1] Antibody, clone 7F9.2, Alexa Fluor 488 conjugate is an antibody against OCT-4 [POU5F1] for use in ICC.

Qualità

Evaluated by Immunocytochemistry in mouse embryonic stem cells (SCR012). Immunocytochemsitry Analysis: A 1:100 dilution of this antibody detected Oct-4 in mouse embryonic stem cells (SCR012).

Descrizione del bersaglio

The uncojugated parent antibody (Catalog No. MAB4419) has an observed MW at 39 kDa

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

ALEXA FLUOR is a trademark of Life Technologies

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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PloS one, 15(6), e0234262-e0234262 (2020-06-10)
p53 is one of the most extensively studied proteins in cancer research. Mutations in p53 generally abolish normal p53 function, and some mutants can gain new oncogenic functions. However, the mechanisms underlying p53 mutation-driven cancer remains to be elucidated. Our
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International journal of molecular medicine, 35(3), 569-578 (2014-12-20)
The present study aimed to investigate the X chromosome inactivation (XCI) status in long-term cultured human parthenogenetic embryonic stem cells. One human embryonic stem (hES) cell line and 2 human parthenogenetic embryonic stem (hPES) cell lines were subjected to long-term
Tingting Cheng et al.
Oncotarget, 8(5), 7814-7826 (2016-12-22)
Primordial germ cells (PGCs) derived from human embryonic stem cells (hESCs) represent as a desirable experimental model as well as a potential strategy for treating male infertility. Here, we developed a simple and feasible method for differentiation of PGCs from
Melissa Conti Mazza et al.
Stem cell research, 55, 102506-102506 (2021-08-23)
Mutations in the oncogene PARK7, which codes for DJ-1, have been associated with early-onset autosomal recessive Parkinson's disease (PD); however, the exact role of DJ-1 in PD remains elusive. Fibroblasts from a PD patient with a uniparental disomy, 1 bp deletion
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Molecular medicine reports, 15(4), 2049-2056 (2017-03-06)
Focal cortical dysplasia (FCD) is caused by numerous alterations, which can be divided into abnormalities of the cortical architecture and cytological variations; however, the exact etiology of FCD remains unknown. The generation of induced pluripotent stem cells (iPSCs) from the

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