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Merck
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Key Documents

MAB1613

Sigma-Aldrich

Anti-Kinesin Antibody, heavy chain, non-neuronal KHC, clone H1

clone H1, Chemicon®, from mouse

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

100

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

H1, monoclonal

Reattività contro le specie

rat, human, bovine

Produttore/marchio commerciale

Chemicon®

tecniche

ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
radioimmunoassay: suitable
western blot: suitable

Isotipo

IgG1

N° accesso NCBI

NM_004521.1

N° accesso UniProt

P33176

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... KIF5B(3799)

Specificità

Reacts with the major form of heavy chain of non-neuronal KHC near the N-terminus.

Immunogeno

Epitope: heavy chain, non-neuronal KHC

Applicazioni

Anti-Kinesin Antibody, heavy chain, non-neuronal KHC, clone H1 detects level of Kinesin & has been published & validated for use in ELISA, IP, RIA, WB, IC, IH.
Immunohistochemistry on paraformaldehyde fixed tissue. Also works for EM.

Immunocytochemistry: paraformaldehyde fixed cells; 5-10′ RT, freshly made 4% PFA; permeabilize with 0.1-.2% triton X-100 in 3% normal serum blocking buffer

Immunoblotting: recognizes 124kDa KHC from non-neuronal samples.

Immunoprecipitation

Inhibition of kinesin mediated transport

EIA/RIA

Optimal working dilutions must be determined by the end user.

Stato fisico

Format: Purified
Liquid in 0.02 M Phosphate buffer, 0.25 M NaCl.pH 7.6 with 0.1% sodium azide.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic.
Lippincott-Schwartz, J, et al.
The Journal of cell biology, 128, 293-306 (1995)
G Vancoillie et al.
The Journal of investigative dermatology, 114(3), 421-429 (2000-02-26)
Microtubuli play an important role in the organization of organelles and membrane traffic. They are present in melanocytic dendrites through which melanosomes are transported towards keratinocytes. Besides the actin-based motility systems, microtubuli-associated motor proteins also play a critical role in
Wen-Jun Wang et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(1), 62-69 (2013-10-12)
Previous studies identified a family of organic anion transport proteins (OATPs), many of which have C-terminal PDZ binding consensus sequences. In particular, the C-terminal four amino acids of Oatp1a1, a transporter on rat and mouse hepatocytes, comprise a consensus binding
Hongtao Chen et al.
Biophysical journal, 94(4), 1508-1520 (2007-11-06)
The role of cholesterol in the regulation of endosome motility was investigated by monitoring the intracellular trafficking of endocytosed folate receptors (FRs) labeled with fluorescent folate conjugates. Real-time fluorescence imaging of HeLa cells transfected with green fluorescent protein-tubulin revealed that
Submolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration.
Hirokawa, N, et al.
Cell, 56, 867-878 (1989)
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