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Key Documents

MAB1576

Sigma-Aldrich

Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 17F10.2

purified antibody, clone 17F10.2, Chemicon®

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

100

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

17F10.2, monoclonal

Reattività contro le specie

mouse, monkey, rat

Produttore/marchio commerciale

Chemicon®

tecniche

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG1

N° accesso NCBI

NM_000741.2

N° accesso UniProt

P08173

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

mouse ... Chrm4(12672)
rat ... Chrm4(25111)
rhesus monkey ... Chrm4(574195)

Specificità

m4 muscarinic acetylcholine receptor. No reactivity with the other subtypes.

Immunogeno

m4 receptor i3 loop (human), fused to GST

Applicazioni

Immunohistochemistry (rat and monkey)

Western blot (rat, mouse, human): ECL 4-10 μg/mL

Immunoprecipitation (rat)

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
This Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 17F10.2 is validated for use in IC, IP, WB for the detection of Muscarinic Acetylcholine Receptor m4.

Stato fisico

Liquid in 0.02M Phosphate buffer, 0.25 M NaCl, pH=7.6 with 0.1% sodium azide.

Stoccaggio e stabilità

Maintain at 2-8°C in undiluted aliquots for up to 6 months.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Lack of specificity of commercially available antisera: better specifications needed.
Pradidarcheep, W; Labruyere, WT; Dabhoiwala, NF; Lamers, WH
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society null
Taketsugu Hayashi et al.
Cell reports, 30(13), 4433-4444 (2020-04-03)
The ability to infer others' mental states is essential to social interactions. This ability, critically evaluated by testing whether one attributes false beliefs (FBs) to others, has been considered to be uniquely hominid and to accompany the activation of a
Decreased expression and impaired function of muscarinic acetylcholine receptors in the rat hippocampus following transient forebrain ischemia.
Guangming Zhang, Liang Zhang, Richard Logan, Benjamin P Jung, Darren Yuen, Jee Ching Hsu et al.
Neurobiology of Disease null
Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor.
Volpicelli, Laura A, et al.
The Journal of Neuroscience, 22, 9776-9784 (2002)
Keita Harada et al.
Journal of pharmacological sciences, 117(4), 253-264 (2011-11-19)
The muscarinic receptor is known to be involved in the acetylcholine (ACh)-induced secretion of catecholamines in the adrenal medullary (AM) cells of various mammals. The muscarinic receptor subtype involved and its physiological role, however, have not been elucidated yet. Thus
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