ABT334

Anti-TSLP receptor Antibody

from rabbit, purified by affinity chromatography

• Sinonimo/i: TSLP Receptor Antibody, TSLP Receptor, Thymic stromal lymphopoietin receptor, CRL2, ILXR, TSLPR, Cytokine receptor-like factor 2, Cytokine receptor-like 2, IL-XR
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Purificato mediante: affinity chromatography
• Reattività contro le specie: human
• tecniche: immunofluorescence: suitable; immunohistochemistry: suitable (paraffin); western blot: suitable
• N° accesso UniProt: Q9HC73
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... TSLP(85480)

Descrizione

Descrizione generale

Thymic stromal lymphopoietin (TSLP) receptor is a member of the Type I cytokine receptor family (type 5 subfamily). TSLP has been shown to play an important role in dendritic cell maturation and activation. Additionally, TSLP receptor is involved in the positive selection of regulatory T cells, induction of CD4+ T cell-mediated allergic reaction and maintenance of peripheral CD4+ T cell homeostasis. Furthermore, TSLP receptor is implicated in the development of the hematopoietic system. TSLP receptor forms a functional complex with TSLP receptor and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. TSLP receptor is primarily expressed in dendrites and monocytes. Additionally, it is expressed in heart, skeletal muscle, kidney and adult and fetal liver; and weakly expressed in T-cells.

Immunogeno

KLH-conjugated linear peptide corresponding to human TSLP receptor.

Applicazioni

Detect TLSP Receptor using this rabbit polyclonal antibody, Anti-TSLP receptor Antibody validated for use in western blotting, IHC (Paraffin) & Immunofluorescence.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected TSLP receptor in human liver tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected TSLP receptor in human liver cells.

Research Category
Signaling

Research Sub Category
Cytokines & Cytokine Receptors

Qualità

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected TSLP receptor in 15 µg of human liver tissue lysate.

Descrizione del bersaglio

~53 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~27 kDa and ~42 kDa

Stato fisico

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
Human liver tissue lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable