Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

AB5849

Sigma-Aldrich

Anti-Glutamate Receptor 1 Antibody, phosphoSer 845

Chemicon®, from rabbit

Sinonimo/i:

GluR1

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali


About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Forma dell’anticorpo

affinity purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

rat

Confezionamento

antibody small pack of 25 μL

Produttore/marchio commerciale

Chemicon®

tecniche

western blot: suitable

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

phosphorylation (pSer845)

Informazioni sul gene

human ... GRIA1(2890)

Descrizione generale

Glutamate receptor 1 (AMPA) belongs to the glutamate-gated ion channel and binds AMPA, glutamate and kainate. L-Glutamate is the major excitatory neurotransmitter in the mammalian CNS, acting through both ligand gated ion channels (ionotropic receptors; composed of subunits GluR1-4) and G-protein coupled (metabotropic) receptors. The AMPA glutamate receptors mediate fast synaptic transmission in the CNS.

Specificità

Recognizes Glutamate Receptor 1 [GluR1], phosphoSe845. The antibody recognizes a protein of 100 kDa corresponding to GluR1 phosphorylated at Ser845.

Immunogeno

Epitope: phosphoSer 845
Synthetic peptide corresponding to amino acids surrounding the phosphoSer845 of rat GluR1.

Applicazioni

Anti-Glutamate Receptor 1 Antibody, phosphoSer 845 is an antibody against Glutamate Receptor 1 for use in WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Western blot: 1:1,000

Optimal working dilutions must be determined by the end user.

Descrizione del bersaglio

100 kDa

Stato fisico

Affinity Purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
ImmunoAffinity Purified

Stoccaggio e stabilità

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Risultati analitici

Control
Human brain tissue

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Non trovi il prodotto giusto?  

Prova il nostro Motore di ricerca dei prodotti.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Alan Rembach et al.
Journal of neuroscience research, 77(4), 573-582 (2004-07-21)
Glutamate excitotoxicity is strongly implicated as a major contributing factor in motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Excitotoxicity results from elevated intracellular calcium ion (Ca(2+)) levels, which in turn recruit cell death signaling pathways. Recent evidence suggests that
Equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase - dual targets of the endocannabinoid system to protect against seizure pathology.
Naidoo, Vinogran, et al.
Neurotherapeutics, 9, 801-813 (2012)
Increased insertion of GluR2-lacking AMPA receptors at hippocampal synapses upon repeated morphine administration.
Billa SK, Liu J, Bjorklund NL, Sinha N, Fu Y, Shinnick-Gallagher P, Mor??n JA
Molecular Pharmacology null
Evidence for a developmental role for TLR4 in learning and memory.
Okun, E; Barak, B; Saada-Madar, R; Rothman, SM; Griffioen, KJ; Roberts, N; Castro et al.
Testing null
Learning-induced glutamate receptor phosphorylation resembles that induced by long term potentiation.
Shukla, K; Kim, J; Blundell, J; Powell, CM
The Journal of Biological Chemistry null

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.