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Key Documents

AB5561

Sigma-Aldrich

Anti-GABA A Receptor β2 Antibody, cytoplasmic loop

Chemicon®, from rabbit

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Forma dell’anticorpo

affinity purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

rat, mouse, bovine, human

Produttore/marchio commerciale

Chemicon®

tecniche

immunoprecipitation (IP): suitable
western blot: suitable

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... GABRB2(2561)

Specificità

GABAA receptor beta2 subunit. The antibody is specific for the ~50 to 56kDa in rat brain membrane fractions.

Immunogeno

MBP fusion protein from the cytosolic loop of rat GABAA receptor beta2 subunit.

Applicazioni

Anti-GABA A Receptor β2 Antibody, cytoplasmic loop is an antibody against GABA A Receptor β2 for use in IP & WB.
Western blot: 1:1,000

Immunopreciptation: The antibody will immunoprecipitate 68% of all GABAA receptors in dodecylsulfate extracts of rat forebrains (150 μL) using 15 μg of antibody.

Optimal working dilutions must be determined by the end user.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2


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GABA(A) receptor alpha1 subunit mutation A322D associated with autosomal dominant juvenile myoclonic epilepsy reduces the expression and alters the composition of wild type GABA(A) receptors.
Ding, L; Feng, HJ; Macdonald, RL; Botzolakis, EJ; Hu, N; Gallagher, MJ
The Journal of Biological Chemistry null
Evangelos Sotiriou et al.
Journal of neuroscience research, 82(5), 690-700 (2005-11-08)
Recent data demonstrate weaker gamma-aminobutyric acid (GABA)-ergic inhibition in ventral (VH) compared with dorsal (DH) hippocampus. Therefore, we examined possible differences regarding the GABAA receptors between VH and DH as follows: 1) the expression of the GABAA receptor subunits (alpha1/2/4/5
Jingjing Duan et al.
Frontiers in cellular neuroscience, 13, 217-217 (2019-06-25)
In the adult brain GABAA receptors (GABAARs) mediate the majority of synaptic inhibition that provides inhibitory balance to excitatory drive and controls neuronal output. In the immature brain GABAAR signaling is critical for neuronal development. However, the cell-autonomous role of
Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.
Zhou, C; Huang, Z; Ding, L; Deel, ME; Arain, FM; Murray, CR; Patel, RS; Flanagan, CD; Gallagher, MJ
The Journal of Biological Chemistry null
Timothy A Warner et al.
Human molecular genetics, 25(15), 3192-3207 (2016-06-25)
Genetic epilepsy is a common disorder with phenotypic variation, but the basis for the variation is unknown. Comparing the molecular pathophysiology of mutations in the same epilepsy gene may provide mechanistic insights into the phenotypic heterogeneity. GABRG2 is an established

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